Validation of the 6 MV TrueBeam linear accelerator model for out-of-field radiation dose calculation using PHITS Monte Carlo code
Main Article Content
Abstract
Background: Radiotherapy treatment planning usually concerns in-field radiation dose to produce a high therapeutic ratio with high dose to the target and minimum normal tissue complication. However, out-of-field radiation dose should also be considered because it causes additional radiation exposure to the patient, resulting in an increased risk for developing secondary cancer in the patient and health consequences in the fetus if the patient is pregnant. Monte Carlo simulation is useful for estimating out-of-field dose. The American Association of Physicists in Medicine Task Group 158 (AAPM TG 158) recommends that Monte Carlo simulation for calculation of out-of-field radiation dose should be validated in terms of percentage depth dose, lateral beam profile, dose near the phantom surface and peripheral dose.
Objectives: To validate the 6 MV TrueBeam linear accelerator model developed using Particle and Heavy Ion Transport code System (PHITS) Monte Carlo code for out-of-field dose calculation for the field sizes of 10x10, 10x20 and 40x40 cm2.
Materials and methods: The Monte Carlo simulation was validated against experimental data at the same conditions. Percentage depth dose, lateral beam profile and dose near the phantom surface were measured at 10x10, 10x20, and 40x40 cm2 field sizes, while peripheral doses were measured using 10x10 cm2 field size at 0, 5, 10 and 15 cm distances from the field edge and at 5 and 10 cm depths in a water phantom. The 6 MV radiation fields were delivered using Varian TrueBeam linear accelerator. For the Monte Carlo simulation, phase space data above the jaws were provided by the vendor. PHITS code version 3.20 was used for modeling the treatment head downstream of the phase space surface and the measurement set-up. The gamma evaluation method was used to compare between the calculation and the measurement.
Results: The experimental data and the Monte Carlo simulation were in good agreement. The gamma passing rates with 3%/3mm criteria were 100% for percentage depth dose, 95% for lateral beam profile, 50% for dose near the phantom surface and 81% for peripheral dose.
Conclusion: The 6 MV TrueBeam linear accelerator model developed using PHITS Monte Carlo code was validated according to the AAPM TG 158’s recommendation. The simulation results showed good agreement with the experimental data. Therefore, this Monte Carlo model can be used for out-of-field dose calculation.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.
References
Mazonakis M, Damilakis J. Estimation and reduction of the radiation dose to the fetus from external-beam radiotherapy. Phys Med. 2017; 43: 148-52. doi: 10.1016/j.ejmp.2017.09.130.
D'Arienzo M, Masciullo SG, Sanctis VD, Osti MF, Chiacchiararelli L, Enrici RM. Integral dose and radiation-induced secondary malignancies: comparison between stereotactic body radiation therapy and three-dimensional conformal radiotherapy. Int J Environ Res Public health. 2012; 9(11): 4223-40. doi: 10.3390/ijerph9114223.
Taylor ML, Kron T. Consideration of the radiation dose delivered away from the treatment field to patients in radiotherapy. J Med Phys. 2011; 36(2): 59. doi: 10.4103/0971-6203.79686.
Kry SF, Bednarz B, Howell RM, Dauer L, Followill D, Klein E, et al. AAPM TG 158: measurement and calculation of doses outside the treated volume from external‐beam radiation therapy. Med Phys. 2017; 44(10): e391-e429. doi: 10.1002/mp.12462.
Bednarz B, Xu XG. Monte Carlo modeling of a 6 and 18 MV Varian Clinac medical accelerator for in-field and out-of-field dose calculations: development and validation. Phys Med Biol. 2009; 54(4): N43. doi: 10.1088/0031-9155/54/4/N01.
Kry SF, Titt U, Pönisch F, Followill D, Vassiliev ON, Allen White R, et al. A Monte Carlo model for calculating out‐of‐field dose from a Varian beam. Med Phys. 2006; 33(11): 4405-13. doi: 10.1118/1.2360013.
Wijesooriya K, Liyanage NK, Kaluarachchi M, Sawkey D. Part II: Verification of the TrueBeam head shielding model in Varian VirtuaLinac via out‐of‐field doses. Med Phys. 2019; 46(2): 877-84. doi: 10.1002/mp.13263.
Siji C, Mustafa M, Ganapati R. Out-of-field photon dosimetry study between 3-D conformal and intensity modulated radiation therapy in the management of prostate cancer. J Radiat Res. 2015; 13(2): 127-34. doi: 10.7508/ijrr.2015.02.002.
Starkschall G, St. George F, Zellmer D. Surface dose for megavoltage photon beams outside the treatment field. Med Phys. 1983; 10(6): 906-10. doi: 10.1118/1.595362.
Apipunyasopon L, Srisatit S, Phaisangittisakul N. An investigation of the depth dose in the build-up region, and surface dose for a 6-MV therapeutic photon beam: Monte Carlo simulation and measurements. J Radiat Res. 2013; 54(2): 374-82. doi: 10.1093/jrr/rrs097.
Kry SF, Salehpour M, Titt U, White RA, Stovall M, Followill D. Monte Carlo study shows no significant difference in second cancer risk between 6-and 18-MV intensity-modulated radiation therapy. Radiother Oncol. 2009; 91(1): 132-7. doi: 10.1016/j.radonc.2008.11.020.
Varian Medical System. TrueBeamMonteCarloDataPackage version 1.1. California: Varian Medical system; 2014.
Furuta T, Hashimoto S, Sato T. Medical Applications of the PHITS Code (3): User Assistance Program for Medical Physics Computation. Japanese journal of medical physics: an official journal of Japan Society of Medical Physics. 2016; 36(1): 50-4. doi: 10.11323/jjmp.36.1_50.
Sato T, Iwamoto Y, Hashimoto S, Ogawa T, Furuta T, Abe S-i, et al. Features of particle and heavy ion transport code system (PHITS) version 3.02. Journal of Nuclear Science and Technology. 2018; 55(6): 684-90. doi: 10.1080/00223131.2017.1419890.
Low DA, Harms WB, Mutic S, Purdy JA. A technique for the quantitative evaluation of dose distributions. Med Phys. 1998; 25(5): 656-61. doi: 10.1118/1.598248.
Venselaar J, Welleweerd H, Mijnheer B. Tolerances for the accuracy of photon beam dose calculations of treatment planning systems. Radiother Oncol. 2001 Aug 1; 60(2): 191-201. doi: 10.1016/s0167-8140(01)00377-2.
Chetty IJ, Curran B, Cygler JE, DeMarco JJ, Ezzell G, Faddegon BA, Kawrakow I, Keall PJ, Liu H, Ma CM, Rogers DW. AAPM Task Group Report No. 105;“Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning,”. Med Phys. 2007; 34: 4818-52. doi: 10.1118/1.2795842.
Shende R, Gupta G, Patel G, Kumar S. Commissioning of TrueBeam TM medical linear accelerator: quantitative and qualitative dosimetric analysis and comparison of flattening filter (FF) and flattening filter free (FFF) beam. Int'l J. of Medical Physics, Clinical Eng. and Radiation Oncology. 2016; 5(01): 51.
Klein EE, Esthappan J, Li Z. Surface and buildup dose characteristics for 6, 10, and 18 MV photons from an Elekta Precise linear accelerator. J App Clin Med Phys. 2003; 4(1): 1-7. doi: 10.1120/jacmp.v4i1.2537.
Kry SF, Titt U, Followill D, Pönisch F, Vassiliev ON, White RA, et al. A Monte Carlo model for out‐of‐field dose calculation from high‐energy photon therapy. Med Phys. 2007; 34(9): 3489-99. doi: 10.1118/1.2756940.