Rapid alternative methods for erythrocyte sedimentation rate measurement
Main Article Content
Abstract
Background: Erythrocyte sedimentation rate (ESR) measurement is the most widely used in laboratory test to assess an inflammation or acute phase response.
Objectives: To introduce two rapid alternative methods for ESR measurement.
Materials and methods: ESR was performed in 449 blood samples using Westergren, Wintrobe with centrifugation (Win-C) and capillary tube (Cap-C) with centrifugation methods.
Results: Win-C and Cap-C methods were significantly correlated with Westergren method by using Spearman rank correlation. Both Win-C and Cap-C methods were demonstrated the good % of sensitivity, % of specificity, % of positive predictive value, % of negative predictive value and cut-off point by using the receiver operating characteristic (ROC) curves analysis.
Conclusion: Both methods demonstrated acceptable agreement with the conventional ESR measurements and appear to be a faster, easier and safety.
Article Details
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Personal views expressed by the contributors in their articles are not necessarily those of the Journal of Associated Medical Sciences, Faculty of Associated Medical Sciences, Chiang Mai University.
References
[2] Jou J, Lewis S, Briggs C, Lee SH, De La Salle B, McFadden S, et al. ICSH review of the measurement of the erythrocyte sedimentation rate. Int J Lab Hematol 2011; 33: 125-32.
[3] Westergren A. The technique of the red cell sedimentation reaction. Am Rev Tuberc 1926; 14: 94-101.
[4] Alexy T, Pais E, Meiselman HJ. A rapid method to estimated Westergren sedimentation rates. Rev Sci Instrum 2009; 80: 096102.
[5] Swets JA. Measuring the accuracy of diagnostic systems. Science 1988; 240: 1285-93.
[6] Arikan S, Akalin N. Comparison of the erythrocyte sedimentation rate measured by the micro test 1 sedimentation analyzer and the conventional Westergren method; Ann Saudi Med 2007; 27: 362-5.
[7] Saadeh C. The erythrocyte sedimentation rate: old and new clinical applications; South Med J. 1998; 91: 220-25.
[8] Vennapusa B, DeLaCruz L, Shah H, Michalski V, Zhang QY. Erythrocyte sedimentation rate (ESR) measured by the streck ESR-auto plus is higher than with the sediplast Westergren method. Am J Clin Pathol 2011; 135: 386-90.
[9] ICSH Expert Panel. Guidelines on the selection of laboratory tests for monitoring the acute phase response. J Clin Pathol 1998; 41: 1203-12.
[10] Pawlotsky Y, Goasguen J, Guggenbuhl P, Veillard E, Jard C, Pouchard M, et al. Sigma ESR: an erythrocyte sedimentation rate adjusted for the hematocrit and hemoglobin concentration. Am J Clin Pathol 2004; 122(5):802-10.
[11] Hashemi R, Majidi A, Motamed H, Amini A, F Najari, Tabatabaey A. Erythrocyte sedimentation rate measurement using as a rapid alternative to the Westergren method. Emergency 2015; 3(2):50-3.