Factors Predicting Health-Related Quality of Life Among People Living with Breast Cancer Undergoing Chemotherapy
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This study aimed to: (1) examine the health-related quality of life (HRQoL) among people living with breast cancer undergoing chemotherapy, and (2) investigate the predictive power of age, number of chemotherapy sessions, social support, chemotherapy side effects, and health-promoting behaviors on HRQoL. The sample consisted of 148 female patients aged 18 years and older who were diagnosed with breast cancer and follow up to receive chemotherapy at the outpatient department of King Chulalongkorn Memorial Hospital, Thai Red Cross Society. Participants were selected based on predefined inclusion criteria. The research instruments included: (1) personal information questionnaire, (2) social support questionnaire, (3) chemotherapy side effects questionnaire, (4) health-promoting behaviors questionnaire, and (5) breast cancer-specific HRQoL questionnaire. Instruments 2–4 were validated for content using the Content Validity Index (CVI), with CVI scores of .90, 1.0, and .90, respectively. Their reliability, assessed by Cronbach's alpha coefficients, were .88, .80, and .84, respectively. Data were analyzed using descriptive statistics and multiple regression analysis. The results showed that the HRQoL among breast cancer patients receiving chemotherapy was at a moderate level (M = 62.93, SD = 16.06). Health-promoting behaviors (β = .74, p < .001), social support (β = .42, p < .001), chemotherapy side effects (β = –.39, p < .001), and the number of chemotherapy sessions (β = –.23, p < .001) were significant predictors of HRQoL, collectively explaining 15.88% of the variance (p < .05).
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