The Influence of Unpleasant Symptoms on Functional Status of Advanced Cancer Patients Receiving Chemotherapy


  • Thidarat Khamboon Asst. Prof.Dr.
  • Intira Pakanta
  • Pannee Suwanmongkol
  • Supicha Ardkhitkarn


Functional status, Patients with Advanced Cancer, Chemotherapy, Unpleasant Symptom


Cancer is a major health problem in Thailand. The severity of the disease is increasing, especially in patients with advanced cancer. Chemotherapy is the most common treatment option for patients with advanced cancer. Patients with advanced cancer often experience several unpleasant symptoms both from disease and treatment-related side effects, affecting reduced functional status. Thus, unpleasant symptom factors influencing the functional status of advanced cancer patients receiving chemotherapy would promote their functional status.

This was descriptive correlational research. This research aimed to investigate the influence of unpleasant symptoms on the functional status of advanced cancer patients receiving chemotherapy. The sample included 500 advanced cancer patients receiving chemotherapy at the department of chemotherapy unit of a center hospital in the lower northern region of Thailand from March 2020 to October 2021.  Data were collected using questionnaires on demographic characteristics, Edmonton Symptom Assessment Scale, and the Inventory Functional Status-CA. Descriptive statistics by frequency, percentage, mean, standard deviation, and predictive testing by multiple regression were used for data analysis.  The results revealed that the unpleasant symptoms influencing the functional status of advanced cancer patients receiving chemotherapy statistically significant at the .05 level were impaired well-being (Beta = -.233), tiredness or fatigue (Beta = -.228), pain (Beta = -.210), and nausea (Beta = -.133), which were explained 22.30 % of the variance of functional status. From the results of this study, the data can be used for developing a program to manage these unpleasant symptoms to improve the functional status of advanced cancer patients receiving chemotherapy.


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How to Cite

Khamboon, T., Pakanta, I. ., Suwanmongkol, P. ., & Ardkhitkarn, S. . (2022). The Influence of Unpleasant Symptoms on Functional Status of Advanced Cancer Patients Receiving Chemotherapy. NU Journal of Nursing and Health Sciences, 16(3), 85–96. Retrieved from