Surgical Outcomes of Single Posterior Approach for Spinal Tuberculosis with Neurological Deficits
Main Article Content
Abstract
The spine is the most common site for skeletal involvement in tuberculosis (TB). Antitubercular drugs are the mainstay of treatment for spinal TB. Due to controversies surrounding the outcomes of surgical treatment, we conducted a retrospective study aimed at determining clinical and radiographic outcomes in patients with spinal TB and neurological deficits who underwent surgical treatment with a single posterior approach. Data were collected from patients treated for spinal TB at Pranangklao Hospital from 2016 to 2022. Ten patients underwent surgical treatment with a 12-month follow-up. The average age was 62.1 years. The most common location was the thoracic spine. Before surgery, one patient was classified as Frankel A, four patients as Frankel B, and five patients as Frankel C. The mean operative time was 167.2 minutes, and blood loss was 883.3 ml. The neurological outcome at 3 months postoperatively was significantly improved compared to the preoperative state (p = 0.03). At the last follow-up, six patients were classified as Frankel D, and four patients were classified as Frankel E. The posterior approach to the spine with decompression and fixation provides good neurological results for patients with spinal tuberculosis.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Tuli SM. Tuberculosis of the spine: a historical review. Clin Orthop Relat Res. 2007;460:29-38. doi:10.1097/BLO.0b013e31 8065b75e
Bodapati PC, Vemula RCV, Mohammad AA, Mohan A. Outcome and management of spinal tuberculosis according to severity at a tertiary referral center. Asian J Neurosurg 2017;12:441-6. doi: 10.4103/1793-5482.180924
Moorthy S, Prabhu NK. Spectrum of MR imaging findings in spinal tuberculosis. AJR Am J Roentgenol 2002;179(4):979 83.
Tuli SM. Treatment of neurological complications in tuberculosis of the spine. J Bone Joint Surg Am 1969;51(4):680 92.
Rajasekaran S, Khandelwal G. Drug therapy in spinal tuberculosis. Eur Spine J 2013;22 Suppl 4:587 93.
Eighth Report of the Medical Research Council Working Party on Tuberculosis of the Spine. A 10-year assessment of a controlled trial comparing debridement and anterior spinal fusion in the management of tuberculosis of the spine in patients on standard chemotherapy in Hong Kong. J Bone Joint Surg Br 1982;64(3):393-8.
Halsey JP, Reeback JS, Barnes CG. A decade of skeletal tuberculosis. Ann Rheum Dis 1982;41:7 10.
Soares do Brito J, Batista N, Tirado A, Fernandes P. Surgical treatment of spinal tuberculosis: An orthopedic service experience. Acta Med Port 2013;26:349 56.
Hafez AR, Fattouh M. One-stage posterior instrumentation and fusion for the treatment of tuberculous spondylodiscitis of dorsal and lumbar spine. J Am Sci 2012;8:85-90.
Garg B, Kandwal P, Nagaraja UB, Goswami A, Jayaswal A. Anterior versus posterior procedure for surgical treatment of thoracolumbar tuberculosis: a retrospective analysis. Indian J Orthop 2012;46:165-7.
Pandita A, Madhuripan N, Pandita S, Hurtado RM. Challenges and controversies in the treatment of spinal tuberculosis. J Clin Tuberc Other Mycobact Dis. 2020;19:100151. doi:10.1016/j.jctube.2020.100151
Luan H, Liu K, Wang Y, Kahaer A, Sheng W, Maimaiti M, et al. Efficacy of anterior debridement and bone grafting with fusion using internal fixation combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical tuberculosis. BMC Surg. 2022;22(1):150. doi:10.1186/s12893-022-01606-y
Bai J, Xia Q, Miao J. Combined anteroposterior approaches in lateral position treatment of lumbosacral tuberculous in single-stage. BMC Surg. 2022;22(1):154. doi:10.1186/s12893-022-01612-0
Du X, Ou Y, Luo W, Jiang G, Qin W, Zhu Y. Evaluation of the efficacy of OLIF combined posterior internal fixation for single-segment lumbar tuberculosis: a single-center retrospective cohort study. BMC Surg. 2022;22(1):54. doi:10.1186/s12893-022-01492-4
Su SH, Tsai WC, Lin CY, Lin WR, Chen TC, Lu PL,et al. Clinical features and outcomes of spinal tuberculosis in southern Taiwan. J Microbiol Immunol Infect 2010;43 (4):291–300. doi:10.1016/S1684-1182(10)60046-1
Park DW, Sohn JW, Kim EH, Cho DI, Lee JH, Kim KT, et al. Outcome and management of spinal tuberculosis according to the severity of disease: a retrospective study of 137 adult patients at Korean teaching hospitals. Spine. 2007;32(4):E130–5. doi:10.1097/01.brs.0000255216.54085.21
Chen WJ, Chen CH, Shih CH. Surgical treatment of tuberculous spondylitis. 50 patients followed for 2–8 years. Acta Orthop Scand. 1995;66(2):137–42. doi:10.3109/17453679508995507
Jutte PC, van Loenhout-Rooyackers JH. Routine surgery in addition to chemotherapy for treating spinal tuberculosis. Cochrane Database Syst Rev. 2006; 5:CD004532. doi:10.1002/14651858.CD004532.pub2
Zhang Z, Luo F, Zhou Q, Dai F, Sun D, Xu J. The outcomes of chemotherapy only treatment on mild spinal tuberculosis. J Orthop Surg Res 2016;11(1):49. doi:10.1186/s13018-016-0385-y
Frankel HL, Hancock DO, Hyslop G, Melzak J, Michaelis LS, Ungar GH, et al. The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia: I. Paraplegia 1969;7:179-92
Muangchan C, Nilganuwong S. The study of clinical manifestation of osteoarticular tuberculosis in Siriraj Hospital, Thailand. J Med Assoc Thai 2009;92 Suppl 2:S101-9.
Rivas-Garcia A, Sarria-Estrada S, Torrents-Odin C, et al. Imaging findings of Pott’s disease. Eur Spine J 2013;22 Suppl 4:567-78.
Lee KY. Comparison of pyogenic spondylitis and tuberculous spondylitis. Asian Spine J 2014;8:216-23.
Rasouli MR, Mirkoohi M, Vaccaro AR, Yarandi KK, Movaghar VR. Spinal tuberculosis: diagnosis and management. Asian Spine J 2012;6:294-308.
Graham SM. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children.Malawi Med J 2007 Jun; 19(2): 82–6.
Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Treatment of tuberculosis. Am J Respir Crit Care Med 2003;167:603 62
Phalak M, Kale SS. Tuberculosis of the thoracic spine- when and how to operate. Current practice in Neurosciences. 2019;1:1-12.
D’souza AR, Mohapatra B, Bansal ML, Das K. Role of posterior stabilization and transpedicular decompression in the treatment of thoracic and thoracolumbar TB: A retrospective evaluation. Clin Spine Surg 2017;30:E1426 33.
Zhang H, Sheng B, Tang M, Guo C, Liu S, Huang S, et al. One stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via posterior only approach. Eur Spine J 2013;22:616 23.
Jain A, Jain RK, Kiyawat V. Evaluation of outcome of transpedicular decompression and instrumented fusion in thoracic and thoracolumbar tuberculosis. Asian Spine J 2017;11:31 6.
Rath SA, Neff U, Schneider O, Richter HP. Neurosurgical management of thoracic and lumbar vertebral osteomyelitis and discitis in adults: A review of 43 consecutive surgically treated patients. Neurosurgery 1996;38:926 33.
Güven O, Kumano K, Yalçin S, Karahan M, Tsuji S. A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis. Spine (Phila Pa 1976) 1994;19:1039 43.
Cui X, Ma YZ, Chen X, Cai XJ, Li HW, Bai YB. Outcomes of different surgical procedures in the treatment of spinal tuberculosis in adults. Med Princ Pract 2013;22:346 50.