Potential Role of Soluble Angiotensin-Converting Enzyme 2 In Salivary Coronavirus Infection Therapy

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Attapon Cheepsattayakorn


Angiotensin-converting  enzyme 2 (ACE 2), a  monocarboxypeptidase  for  cleaving  several  peptides  within  the  renin-angiotensin  system  and  other  substrates  that  widely  expressed  in  the  gastrointestinal  tract  and  the  kidneys, with  relatively  low  expression  in  the  lungs [1, Figure 1].   Interestingly, higher  RNA  expression  of  ACE 2  in  lung  AT2  cells  was  found  in  Asian  donors, compared  to  African  and  white  American  donors [2].  Soluble  ACE 2  that  lacks  the  membrane  anchor  circulates  in  small  volumes  in  the  blood [3].  ACE 2  and  TMPRSS 2  protein  expression  are  identified  mainly  in  the  cytoplasm  and  cytomembrane  of  the  epithelial  cells  in  the  serous  acinus  cells  in  submandibular  and  parotid  salivary  glands  and  in  vitro, exogenous  ACE 2  and  TMPRSS 2  can  anchor  and  fuse  to  human  oral  mucosa  and  the  spike  protein  of  SARS-CoV-2  can  bind  to  ACE 2  receptors  in  the  salivary  glands [4].  A  recent  study  demonstrated  that  during  the  hospitalization  period, 25 %  of  COVID-19  patients  reported  of  taste  impairment, 20 %  of  patients  reported  of  difficulty  in  swallowing, and  15 %  of  patients  reported  of  burning  sensation [5].  A  recent  study  proposed  that  chewing  gum  with  SARS-CoV-2-trapping  proteins  can  debulking  virus  in  saliva  and  minimizing  viral  transmission


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Cheepsattayakorn A. Potential Role of Soluble Angiotensin-Converting Enzyme 2 In Salivary Coronavirus Infection Therapy . JDPC3 [Internet]. 2022 Apr. 8 [cited 2022 Aug. 15];16(1). Available from: https://he01.tci-thaijo.org/index.php/JDPC3/article/view/255713
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