Association between Medication Discontinuation and Re-hospitalization in Schizophrenia Patients in Khon Kaen Rajanagarindra Psychiatric Hospital: Matched Case-Control Study

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Wanida Butrin
Chananya Jirapornkul
Nasamapon Handee
Naowarat Maneenin

Abstract

       


Objectives: The study was to analyze the association between medication discontinuation and re-hospitalization in schizophrenia patients at Khon Kaen Rajanagarindra Psychiatric Hospital.


Materials and Methods: It was a matched case – control study, by using the secondary data from Electronic Medical Record of Khon Kaen Rajanagarindra Psychiatry Hospital, fiscal years 2015-2019. The study sample was 300 schizophrenic patients. The study group consisted of 150 schizophrenic patients (F20.0-F20.9) who re-hospitalized within 180 days. The control group consisted of 150 schizophrenic patients who did not re-hospitalize within 180 days. Gender and age ±2 years were matched. The association was analyzed by multivariable conditional logistic regression. The association was presented by Adjusted Odds Ratio (ORadj), 95% confidence interval.


Results: Family income, potential of caregivers, and duration of illness were controlled in the final equation, It was found that the medication discontinuation was associated with re-hospitalization among schizophrenic patients in Khon Kaen Rajanagarindra Psychiatric Hospital with statistical significance (p-value < 0.05). The patients with medication discontinuation were 2.0 times more likely to re-hospitalize than those with medication continuation (OR adj = 2.0, 95%CI; 1.15 - 3.47) (p=0.013).


Conclusion: Medication discontinuation was associated with re-hospitalization in schizophrenic patients in Khon Kaen Rajanagarindra Psychiatric Hospital.

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