Indirect costs and related factors for patients with non-small cell lung cancer treated with targeted therapy in Vietnam 10.55131/jphd/2026/240120

Main Article Content

Chinh Van Nguyen
Huong Tran Thi Thanh
Kiet Tuan Pham Huy

Abstract

The objective of our study was to estimate indirect costs and identify the factors affecting them. Additionally, we aimed to determine which age group impacts the component costs of the total indirect costs for non-small cell lung cancer (NSCLC) patients treated with targeted therapy. This cross-sectional descriptive study was conducted through interviews about indirect costs for one month, from October 2022 to December 2023, with 310 NSCLC patients at the Vietnam National Cancer Hospital. All indirect costs were standardized according to the Consumer Price Index (CPI) and converted to 2023 US dollars. The monthly mean total indirect costs for NSCLC patients were $96.0. The rate of caregivers' absence from work was 49%, and 37.7% of patients experienced income loss. However, the highest cost was income loss at $83.3, accounting for 86.8%, while caregivers' absence cost $10.1, accounting for 10.6% of the total indirect costs. The costs of patients’ absence and income loss were higher for patients under 60 years old (p < 0.001 for each group). Factors such as age (under 60), gender (male), and occupation (employed or unemployed) were identified as related to an increase in the total indirect costs for NSCLC patients compared to other groups (p < 0.05 for each group). Support from insurance agencies for patients’ absence and income loss is truly meaningful.

Article Details

How to Cite
1.
Nguyen Van C, Tran Thi Thanh H, Pham Huy Tuan K. Indirect costs and related factors for patients with non-small cell lung cancer treated with targeted therapy in Vietnam: 10.55131/jphd/2026/240120. J Public Hlth Dev [internet]. 2026 Jan. 29 [cited 2026 Feb. 2];24(1):272-83. available from: https://he01.tci-thaijo.org/index.php/AIHD-MU/article/view/277132
Section
Original Articles
Author Biographies

Chinh Van Nguyen, Department of Health Economics, Hanoi Medical University, Hanoi City, Vietnam

Department of Health Economics, Hanoi Medical University, Hanoi City, Vietnam

Huong Tran Thi Thanh, Vietnam National Cancer Institute, Vietnam National Cancer Hospital, Department of Medical

Vietnam National Cancer Institute, Vietnam National Cancer Hospital, Department of Medical

Kiet Tuan Pham Huy, Department of Health Economics, Hanoi Medical University, Hanoi City, Vietnam

Department of Health Economics, Hanoi Medical University, Hanoi City, Vietnam

References

Cao W, Qin K, Li F, Chen W. Socioeconomic inequalities in cancer incidence and mortality: An analysis of GLOBOCAN 2022. Chinese Medical Journal. 2024;137(12):1407. doi:10.1097/CM9.0000000000003140

Sharma R. Mapping of global, regional and national incidence, mortality and mortality-to-incidence ratio of lung cancer in 2020 and 2050. Int J Clin Oncol. 2022;27(4):665-675. doi:10.1007/s10147-021-02108-2

Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung cancer. Nat Rev Dis Primers. 2015;1(1):1-16. doi: 10.1038/nrdp.2015.9

Kutikova L, Bowman L, Chang S, Long SR, Obasaju C, Crown WH. The economic burden of lung cancer and the associated costs of treatment failure in the United States. Lung Cancer. 2005;50(2):143-154. doi: 10.1016/j.lungcan.2005.06.005

Zhang X, Liu S, Liu Y, et al. Economic Burden for Lung Cancer Survivors in Urban China. International Journal of Environmental Research and Public Health. 2017;14(3):308. doi: 10.3390/ ijerph14030308

Produção G, Faria B, do Vale JW, Facin A, Carvalho M. Main challenges in the identification and measurement of indirect costs in projects: a multiple case study. Gestão & Produção. 2020;27. doi:10.1590/ 0104-530x4913

Iragorri N, de Oliveira C, Fitzgerald N, Essue B. The Out-of-Pocket Cost Burden of Cancer Care—A Systematic Literature Review. Curr Oncol. 2021;28(2):1216-1248. doi: 10.3390/curroncol28020117

Oliveira C de, Weir S, Rangrej J, et al. The economic burden of cancer care in Canada: a population-based cost study. Canadian Medical Association Open Access Journal. 2018;6(1):E1-E10. doi:10.9778/cmajo.20170144

Luengo-Fernandez R, Leal J, Gray A, Sullivan R. Economic burden of cancer across the European Union: a population-based cost analysis. Lancet Oncol. 2013;14(12):1165-1174. doi:10.1016/S1470-2045(13) 70442-X

Seung SJ, Hurry M, Hassan S, Walton RN, Evans WK. Cost-of-illness study for non-small-cell lung cancer using real-world data. Curr Oncol. 2019;26(2):102-107. doi:10.3747/co.26.4555

Aminuddin F, Bahari MS, Zainuddin NA, Mohd Hanafiah AN, Mohd Hassan NZA. The Direct and Indirect Costs of Cancer among the Lower-Income Group: Estimates from a Pilot and Feasibility Study. Asian Pac J Cancer Prev. 2023;24(2):489-496. doi:10.31557/APJCP.2023.24.2.489

Fautrel B, Boonen A, Wit M de, Grimm S, Joore M, Guillemin F. Cost assessment of health interventions and diseases. RMD Open. 2020;6(3): e001287. doi:10.1136/rmdopen-2020-001287

Araújo JKL, Silva LM da, Santos CA, Oliveira I da S, Fialho GM, Giglio A del. Assessment of costs related to cancer treatment. Rev Assoc Med Bras. 2020;66:1423-1430. doi: https://doi.org/10.1590/1806-9282. 66.10.1423

Yang Y, Xia Y, Su C, et al. Measuring the indirect cost associated with advanced non-small cell lung cancer: a nationwide cross-sectional study in China. J Cancer Res Clin Oncol. 2023;149(8):4205-4214. doi:10.1007/s00432-022-04258-w

Tran HTT, Nguyen S, Nguyen KK, et al. Lung Cancer in Vietnam. Journal of Thoracic Oncology. 2021; 16(9):1443-1448. doi:10.1016/j.jtho. 2021.06.002

Zarogoulidou V, Panagopoulou E, Papakosta D, et al. Estimating the direct and indirect costs of lung cancer: a prospective analysis in a Greek University Pulmonary Department. Journal of Thoracic Disease. 2015;7(Suppl 1). doi: 10.3978/j.issn.2072-1439.2015.01.57

C Choong, AMM Firouz, AF Jasmin, et al. Time to care: Gender inequality, unpaid care work and time use survey. Khazanah Research Institute. Published online 2019:1-174.

Kiet PHT, Phuong PC, Chinh NV, et al. Direct medical cost of late-stage lung cancer treatment in vietnam based on big data analysis of National Social Health Insurance database 2020. JMR. 2023;172(11):210-216. doi:10.52852/tcncyh.v172i11.1882

Yoo W, Mayberry R, Bae S, Singh K, He Q, Lillard J. A Study of Effects of MultiCollinearity in the Multivariable Analysis. International journal of applied science and technology. 2014;4:9-19.

Kyriazos T, Poga M. Dealing with Multicollinearity in Factor Analysis: The Problem, Detections, and Solutions. Open Journal of Statistics. 2023;13(3):404-424. doi: 10.4236/ ojs.2023.133020

Nipp RD, Kirchhoff AC, Fair D, et al. Financial Burden in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2017;35(30):3474-3481. doi:10.1200/JCO.2016.71.7066

Zullig LL, Peppercorn JM, Schrag D, et al. Financial Distress, Use of Cost-Coping Strategies, and Adherence to Prescription Medication Among Patients With Cancer. JOP. 2013; 9(6S):60s-63s. doi:10.1200/JOP. 2013.000971

Nipp RD, Zullig LL, Samsa G, et al. Coping with cancer treatment-related financial burden. JCO. 2014;32 (31_suppl):161-161. doi:10.1200/jco. 2014.32.31_suppl.161

Kent EE, Forsythe LP, Yabroff KR, et al. Are survivors who report cancer-related financial problems more likely to forgo or delay medical care? Cancer. 2013;119(20):3710-3717. doi:10.1002/cncr.28262

Neugut AI, Subar M, Wilde ET, et al. Association Between Prescription Co-Payment Amount and Compliance With Adjuvant Hormonal Therapy in Women With Early-Stage Breast Cancer. JCO. 2011;29(18):2534-2542. doi:10.1200/JCO.2010.33.3179

Kale HP, Carroll NV. Self-reported financial burden of cancer care and its effect on physical and mental health-related quality of life among US cancer survivors. Cancer. 2016; 122(8):283-289. doi:10.1002/cncr. 29808

Ramsey SD, Bansal A, Fedorenko CR, et al. Financial Insolvency as a Risk Factor for Early Mortality Among Patients With Cancer. JCO. 2016;34(9):980-986. doi:10.1200/ JCO.2015.64.6620

Navaratnam S, Kliewer EV, Butler J, Demers AA, Musto G, Badiani K. Population-based patterns and cost of management of metastatic non-small cell lung cancer after completion of chemotherapy until death. Lung Cancer. 2010;70(1):110-115. doi: 10.1016/j.lungcan.2010.01.012