Knowledge, attitude, and practice (KAP) survey regarding COVID-19 and factors associated with intention to receive a vaccine in kidney transplant recipients: A cross-sectional study 10.55131/jphd/2024/220310

Main Article Content

Tomohiro Takayama
Kohei Unagami
Kazuya Omoto
Satoshi Miyata
Kenzo Takahashi

Abstract

Post-kidney transplant recipients were recommended to take appropriate infection control measures and receive the third or additional doses of COVID-19 vaccines to reduce the risk of severe COVID-19. However, it remained unclear whether prevention of infection was being adequately implemented and what factors were related to vaccination intention. A cross-sectional questionnaire survey was conducted in March 2022 at Yochomachi Clinic in Tokyo, Japan. The purpose of this study was to identify factors associated with vaccine intentions based on the Knowledge, Attitude, and Practice (KAP) survey regarding COVID-19 and how to promote vaccine acceptance to reduce mortality not only during the COVID-19 pandemic but also in future emerging infectious disease pandemics. Of the 497 participants, 435 intended to receive the third dose of COVID-19 vaccines (including those who actually got it), and 62 did not have such intention. Multivariate logistic regression analysis revealed that male sex (OR: 2.856, 95% CI: 1.377-5.921), positive attitude toward COVID-19 (OR: 1.950, 95% CI: 1.399-2.718), and television as a source of information (OR: 4.165, 95% CI: 1.964-8.831) were associated with vaccination intention, whereas patients who trusted family and friends (OR: 0.343, 95% CI: 0.121-0.968) and those who trusted no-one (OR: 0.173, 95% CI: 0.049-0.613) had no vaccination intention. When considering vaccination policies, media outreach to patients should be given high priority, especially for people at higher risk of developing severe symptoms. This approach can promote vaccine acceptance to reduce mortality not only during the COVID-19 pandemic but also in future emerging infectious disease pandemics.

Article Details

How to Cite
1.
Takayama T, Unagami K, Omoto K, Miyata S, Takahashi K. Knowledge, attitude, and practice (KAP) survey regarding COVID-19 and factors associated with intention to receive a vaccine in kidney transplant recipients: A cross-sectional study: 10.55131/jphd/2024/220310. J Public Hlth Dev [Internet]. 2024 Sep. 9 [cited 2024 Nov. 21];22(3):117-31. Available from: https://he01.tci-thaijo.org/index.php/AIHD-MU/article/view/269247
Section
Original Articles
Author Biographies

Tomohiro Takayama, Teikyo University Graduate School of Public Health, Tokyo, Japan

Teikyo University Graduate School of Public Health, Tokyo, Japan

Kohei Unagami, Department of Organ Transplant Medicine, Tokyo Women’s Medical University, Tokyo, Japan

Department of Organ Transplant Medicine, Tokyo Women’s Medical University, Tokyo, Japan

Yocho-machi Clinic, Tokyo, Japan

Kazuya Omoto, Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan

Yocho-machi Clinic, Tokyo, Japan

 

Satoshi Miyata, Teikyo University Graduate School of Public Health, Tokyo, Japan

Teikyo University Graduate School of Public Health, Tokyo, Japan

Kenzo Takahashi, Teikyo University Graduate School of Public Health, Tokyo, Japan

Teikyo University Graduate School of Public Health, Tokyo, Japan

References

Finelli L, Gupta V, Petigara T, Yu K, Bauer KA, Puzniak LA. Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020. JAMA Netw Open. 2021;4(4):e216556. doi: 10.1001/jamanetworkopen.2021.6556

Zhang Y, Luo W, Li Q, Wang X, Chen J, Song Q, et al. Risk Factors for Death Among the First 80 543 Coronavirus Disease 2019 (COVID-19) Cases in China: Relationships Between Age, Underlying Disease, Case Severity, and Region. Clin Infect Dis. 2022;74(4): 630-638. doi: 10.1093/cid/ciab493

Baraniuk C. Where are we with drug treatments for covid-19? BMJ. 2021;373:n1109. doi: 10.1136/bmj. n1109

Avni T, Leibovici L, Cohen I, Atamna A, Guz D, Paul M, Gafter-Gvili A, Yahav D. Tocilizumab in the treatment of COVID-19-a meta-analysis. QJM. 2021;114(8):577-586. doi: 10.1093/ qjmed/hcab142

RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021;384(8):693-704. doi: 10.1056/ NEJMoa2021436

REMAP-CAP Investigators; Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, et al. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021;384(16):1491-1502. doi: 10.1056/ NEJMoa2100433

O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, et al. Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med. 2021;385(13):1184-1195. doi: 10.1056/NEJMoa2109682

Abaluck J, Kwong LH, Styczynski A, Haque A, Kabir MA, Bates-Jefferys E, et al. Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh. Science. 2022; 375(6577):eabi9069. doi: 10.1126/ science.abi9069

Abu-Raddad LJ, Chemaitelly H, Ayoub HH, AlMukdad S, Yassine HM, Al-Khatib HA, et al. Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar. N Engl J Med. 2022;386(19):1804-1816. doi: 10.1056/NEJMoa2200797

Brooks JT, Butler JC. Effectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2. JAMA. 2021; 325(10):998-999. doi: 10.1001/jama. 2021.1505

Dagan N, Barda N, Kepten E, Miron O, Perchik S, Katz MA, et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med. 2021;384(15):1412-1423. doi: 10.1056/NEJMoa2101765

Gonçalves MR, Dos Reis RCP, Tólio RP, Pellanda LC, Schmidt MI, Katz N,et al. Social Distancing, Mask Use, and Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, Brazil, April-June 2020. Emerg Infect Dis. 2021;27(8):2135-2143. doi: 10.3201/eid2708.204757

Greenhalgh T, Jimenez JL, Prather KA, Tufekci Z, Fisman D, Schooley R. Ten scientific reasons in support of airborne transmission of SARS-CoV-2. Lancet. 2021;397(10285):1603-1605. doi: 10.1016/S0140-6736(21)00869-2

Haas EJ, Angulo FJ, McLaughlin JM, Anis E, Singer SR, Khan F, et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet. 2021;397(10287):1819-1829. doi: 10.1016/S0140-6736(21)00947-8

Mayr FB, Talisa VB, Shaikh O, Yende S, Butt AA. Effectiveness of Homologous or Heterologous Covid-19 Boosters in Veterans. N Engl J Med. 2022;386(14):1375-1377. doi: 10.1056/ NEJMc2200415

Moreira ED Jr, Kitchin N, Xu X, Dychter SS, Lockhart S, Gurtman A, et al. Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine. N Engl J Med. 2022;386(20):1910-1921. doi: 10.1056/NEJMoa2200674

Viana Martins CP, Xavier CSF, Cobrado L. Disinfection methods against SARS-CoV-2: a systematic review. J Hosp Infect. 2022;119:84-117. doi: 10.1016/j.jhin.2021.07.014

Wellenius GA, Vispute S, Espinosa V, Fabrikant A, Tsai TC, Hennessy J, et al. Impacts of social distancing policies on mobility and COVID-19 case growth in the US. Nat Commun. 2021;12(1): 3118. doi: 10.1038/s41467-021-23404-5.

Purnell TS, Auguste P, Crews DC, Lamprea-Montealegre J, Olufade T, Greer R, et al. Comparison of life participation activities among adults treated by hemodialysis, peritoneal dialysis, and kidney transplantation: a systematic review. Am J Kidney Dis. 2013;62(5):953-973. doi: 10.1053/ j.ajkd.2013.03.022

Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999; 341:1725-1730. doi: 10.1056/NEJM199912023412303

Von der Lippe N, Waldum B, Brekke FB, Amro AA, Reisaeter AV, Os I. From dialysis to transplantation: a 5- year longitudinal study on self- reported quality of life. BMC Nephrol. 2014; 15:191. doi: 10.1186/1471-2369-15-191.

Hilbrands LB, Duivenvoorden R, Vart P, Franssen CFM, Hemmelder MH, Jager KJ, et al. COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration. Nephrol Dial Transplant. 2020;35(11):1973-1983. doi: 10.1093/ndt/gfaa261

Cravedi P, Mothi SS, Azzi Y, Haverly M, Farouk SS, Pérez-Sáez MJ, et al. COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium. Am J Transplant. 2020;20(11):3140-3148. doi: 10.1111/ajt.16185

Rozen-Zvi B, Yahav D, Agur T, Zingerman B, Ben-Zvi H, Atamna A, et al. Antibody response to SARS-CoV-2 mRNA vaccine among kidney transplant recipients: a prospective cohort study. Clin Microbiol Infect. 2021;27(8):1173.e1-1173.e4. doi: 10.1016/j.cmi.2021.04.028

Miyake K, Endo M, Okumi M, Unagami K, Kakuta Y, Furusawa M, et al. Predictors of return to work after kidney transplantation: a 12-month cohort of the Japan Academic Consortium of Kidney Transplantation study. BMJ Open. 2019;9(10):e031231. doi: 10.1136/bmjopen-2019-031231

World Health Organization. Survey tool and guidance: rapid, simple, flexible behavioural insights on COVID-19 2020. [Internet]. [Cited 2023 February 11]. Available from: https://apps.who.int/iris/handle/10665/333549.

Al-Marshoudi S, Al-Balushi H, Al-Wahaibi A, Al-Khalili S, Al-Maani A, Al-Farsi N, et al. Knowledge, Attitudes, and Practices (KAP) toward the COVID-19 Vaccine in Oman: A Pre-Campaign Cross-Sectional Study. Vaccines (Basel). 2021;9(6):602. doi: 10.3390/vaccines9060602

Ferdous MZ, Islam MS, Sikder MT, Mosaddek ASM, Zegarra-Valdivia JA, Gozal D. Knowledge, attitude, and practice regarding COVID-19 outbreak in Bangladesh: An online-based cross-sectional study. PLoS One. 2020; 15(10):e0239254. doi: 10.1371/ journal.pone.0239254

Kasemy ZA, Bahbah WA, Zewain SK, Haggag MG, Alkalash SH, Zahran E, et al. Knowledge, Attitude and Practice toward COVID-19 among Egyptians. J Epidemiol Glob Health. 2020; 10(4):378-385. doi: 10.2991/jegh.k. 200909.001

Lau LL, Hung N, Go DJ, Ferma J, Choi M, Dodd W, et al. Knowledge, attitudes and practices of COVID-19 among income-poor households in the Philippines: A cross-sectional study. J Glob Health. 2020;10(1):011007. doi: 10.7189/jogh.10.011007

Noreen K, Rubab ZE, Umar M, Rehman R, Baig M, Baig F. Knowledge, attitudes, and practices against the growing threat of COVID-19 among medical students of Pakistan. PLoS One. 2020;15(12):e0243696. doi: 10.1371/journal.pone.0243696

Park DI. Development and Validation of a Knowledge, Attitudes and Practices Questionnaire on COVID-19 (KAP COVID-19). Int J Environ Res Public Health. 2021;18(14):7493. doi: 10.3390/ijerph18147493

Peng Y, Pei C, Zheng Y, Wang J, Zhang K, Zheng Z, et al. A cross-sectional survey of knowledge, attitude and practice associated with COVID-19 among undergraduate students in China. BMC Public Health. 2020; 20(1):1292. doi: 10.1186/s12889-020-09392-z

Reuben RC, Danladi MMA, Saleh DA, Ejembi PE. Knowledge, Attitudes and Practices Towards COVID-19: An Epidemiological Survey in North-Central Nigeria. J Community Health. 2021;46(3):457-470. doi: 10.1007/ s10900-020-00881-1

Siddiquea BN, Shetty A, Bhattacharya O, Afroz A, Billah B. Global epidemiology of COVID-19 knowledge, attitude and practice: a systematic review and meta-analysis. BMJ Open. 2021;11(9):e051447. doi: 10.1136/bmjopen-2021-051447

Zhong BL, Luo W, Li HM, Zhang QQ, Liu XG, Li WT, Li Y. Knowledge, attitudes, and practices towards COVID-19 among Chinese residents during the rapid rise period of the COVID-19 outbreak: a quick online cross-sectional survey. Int J Biol Sci. 2020;16(10):1745-1752. doi: 10.7150/ ijbs.45221

Sakamoto M, Ishizuka R, Ozawa C, Fukuda Y. Health information and COVID-19 vaccination: Beliefs and attitudes among Japanese university students. PLoS One. 2022;17(11): e0277435. doi: 10.1371/journal.pone. 0277435

Latkin CA, Dayton L, Yi G, Colon B, Kong X. Mask usage, social distancing, racial, and gender correlates of COVID-19 vaccine intentions among adults in the US. PLoS One. 2021;16(2): e0246970. doi: 10.1371/journal. pone.0246970

Kessels R, Luyten J, Tubeuf S. Willingness to get vaccinated against Covid-19 and attitudes toward vaccination in general. Vaccine. 2021;39(33):4716-4722. doi: 10.1016/ j.vaccine.2021.05.069

Yoda T, Katsuyama H. Willingness to Receive COVID-19 Vaccination in Japan. Vaccines (Basel). 2021;9(1):48. doi: 10.3390/vaccines9010048

Ward JK, Alleaume C, Peretti-Watel P; COCONEL Group. The French public's attitudes to a future COVID-19 vaccine: The politicization of a public health issue. Soc Sci Med. 2020;265:113414. doi: 10.1016/j.socscimed.2020.113414

Wang J, Jing R, Lai X, Zhang H, Lyu Y, Knoll MD, et al. Acceptance of COVID-19 Vaccination during the COVID-19 Pandemic in China. Vaccines (Basel). 2020;8(3):482. doi: 10.3390/vaccines8030482

Neumann-Bohme S, Varghese NE, Sabat I, Barros PP, Brouwer W, van Exel J, Schreyögg J, Stargardt T. Once we have it, will we use it? A European survey on willingness to be vaccinated against COVID-19. Eur J Health Econ. 2020;21(7):977-982. doi: 10.1007/ s10198-020-01208-6

Troiano G, Nardi A. Vaccine hesitancy in the era of COVID-19. Public Health. 2021;194:245-251. doi: 10.1016/ j.puhe.2021.02.025

Stumpf J, Siepmann T, Lindner T, Karger C, Schwobel J, Anders L, et al. Humoral and cellular immunity to SARS-CoV-2 vaccination in renal transplant versus dialysis patients: A prospective, multicenter observational study using mRNA-1273 or BNT162b2 mRNA vaccine. Lancet Reg Health Eur. 2021;9:100178. doi: 10.1016/ j.lanepe.2021.100178

Benotmane I, Gautier G, Perrin P, Olagne J, Cognard N, Fafi-Kremer S, et al. Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses. JAMA. 2021;3 26(11):1063-1065. doi: 10.1001/ jama.2021.12339

Machida M, Nakamura I, Kojima T, Saito R, Nakaya T, Hanibuchi T, et al. Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic. Vaccines (Basel). 2021;9(3):210. doi: 10.3390/vaccines9030210