An analysis of risk factors for Multidrug Resistant Tuberculosis (MDR-TB): a hospital-based study 10.55131/jphd/2023/210208

Main Article Content

Sri Wahyuningsih
Andi Zulkifli
A. Arsunan Arsin
Ansariadi
Sudirman Nasir
Masyita Muis
Andi Agus Mumang

Abstract

Multidrug Resistant Tuberculosis (MDR-TB) is the world's most serious problem and one of the leading causes of death. Because of its difficult diagnosis, high rates of treatment failure, and death, MDR-TB is a new challenge in TB control programs. The study aims to identify and analyze the risk factors of Multidrug Resistant Tuberculosis (MDR-TB). The study used a case control study design and was conducted at the Labuang Baji Hospital in Makassar City, Indonesia. The sample was 140 people consisting of 70 in the case group and 70 in the control group. Purposive sampling was used to collect the data. Data were analyzed using STATA program with Multiple Logistic Regression. Significant risk factors of Multidrug Resistant Tuberculosis (MDR-TB) were duration of treatment (OR= 5.655 [Cl 95%: 2.507-12.999]; p<0.001), previous treatment history (OR= 4.833 [Cl 95%: 2.092-11.525]; p<0.001), PMO factor (OR= 3.106 [Cl 95%: 1.227-8.338]; p=0.008), compliance with drugs (OR= 10.961 [Cl 95%: 4.640-26.40]; p<0.001), drug side effects (OR=2.521 [Cl 95%: 1.070-6.126]; p=0.020) and protective factor is the complexity of drug regimen (OR= 0.329 [Cl 95%: 0.136-0.768]; p=0.005). It can be concluded that compliance with drugs is a dominant risk factor for MDR-TB. Improved TB control programs by monitoring the treatment of patients who experienced treatment failure (dropout) probably will increase treatment adherence and cut off MDR-TB transmission.

Article Details

How to Cite
1.
Sri Wahyuningsih, Andi Zulkifli, A. Arsunan Arsin, Ansariadi, Sudirman Nasir, Masyita Muis, Andi Agus Mumang. An analysis of risk factors for Multidrug Resistant Tuberculosis (MDR-TB): a hospital-based study: 10.55131/jphd/2023/210208. J Public Hlth Dev [Internet]. 2023 Apr. 24 [cited 2024 Apr. 15];21(2):91-101. Available from: https://he01.tci-thaijo.org/index.php/AIHD-MU/article/view/263189
Section
Original Articles
Author Biographies

Sri Wahyuningsih, Master Program in Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Master Program in Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Andi Zulkifli, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

A. Arsunan Arsin, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Ansariadi, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Indonesia

Sudirman Nasir, Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Indonesia

Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Indonesia

Masyita Muis, Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Indonesia

Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Indonesia

Andi Agus Mumang, Postgraduate school, Hasanuddin University, Indonesia

Postgraduate school, Hasanuddin University, Indonesia

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