Prevalence and risk factors of nosocomial infections in different wards and seasons in two hospitals in northeastern Iran 10.55131/jphd/2022/200113

Main Article Content

Nayyereh Kasiri
Somaye Barzanouni
Seyedeh Nahid Seyedhasani
Hossein Bakhtiari-Dovvombaygi
Tahere Sarboozi-hoseinabadi
Hamideh Yaghoobi
Mohammad Reza Etesamirad
Elham Safaeiyan
Omid Azizi
Mohammad Sarmadi

Abstract

The prevalence of nosocomial infections (NIs) is a significant health issue in developing countries, and the increased incidence rate of these infections results in longer hospital stays, more mental pressures, increased treatment costs, and higher antibiotic resistance. The present study aimed to evaluate the prevalence of NIs in two hospitals from 2011-2018. In total, 1123 patients with a history of NIs, as reported in the NIs surveillance systems of the hospitals, were included in the study. Data analysis was carried out by SPSS version 16 using Chi-square tests to evaluate the relationship between hospital wards, age, and gender. The prevalence of NIs was higher in the training hospital than in the social security hospital. Also, the prevalence of NIs decreased from 2011-2017 but has increased since 2018. The highest prevalence of NIs was related to E. coli (9.35%), with gram-negative bacteria having the highest frequency (36.2%). In addition, the most common location of NIs was the ICU (23.95%). In terms of the site of infection, postoperative infections had the highest prevalence (38.91%). The results were indicative of a significant relationship between mean age and various hospital wards. In addition, there was a significant relationship between the hospitalisation ward and gender. Meanwhile, no significant association was found between age and hospitalisation ward (P<0.05). There is a need for periodic training for all hospital-based agents to reduce NIs, especially in wards where invasive measures are used for treatment.

Article Details

How to Cite
1.
Kasiri N, Barzanouni S, Nahid Seyedhasani S, Bakhtiari-Dovvombaygi H, Sarboozi-hoseinabadi T, Yaghoobi H, Reza Etesamirad M, Safaeiyan E, Azizi O, Sarmadi M. Prevalence and risk factors of nosocomial infections in different wards and seasons in two hospitals in northeastern Iran: 10.55131/jphd/2022/200113. J Public Hlth Dev [Internet]. 2022 Jan. 31 [cited 2024 Apr. 28];20(1):163-74. Available from: https://he01.tci-thaijo.org/index.php/AIHD-MU/article/view/254513
Section
Original Articles
Author Biographies

Nayyereh Kasiri, Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Somaye Barzanouni, Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Seyedeh Nahid Seyedhasani, Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Health Information Technology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Hossein Bakhtiari-Dovvombaygi, Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Tahere Sarboozi-hoseinabadi, Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Nursing, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Hamideh Yaghoobi, Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Nursing, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Mohammad Reza Etesamirad , Vice Chancellery of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Vice Chancellery of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Elham Safaeiyan , Vice Chancellery of Treatment, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Vice Chancellery of Treatment, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Omid Azizi , Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Mohammad Sarmadi, Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Department of Environmental Health Engineering, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

References

Ak O, Batirel A, Ozer S and Čolakoğlu S. Nosocomial infections and risk factors in the intensive care unit of a teaching and research hospital: A prospecive cohort study. Medical science monitor: international medical journal of experimental and clinical research. 2011; 17: PH29.

Wang L, Zhou K-H, Chen W, Yu Y and Feng S-F. Epidemiology and risk factors for nosocomial infection in the respiratory intensive care unit of a teaching hospital in China: A prospective surveillance during 2013 and 2015. BMC infectious diseases. 2019; 19: 145.

Mohajeri P, Azizkhani S, Farahani A and Norozi B. Genotyping of coa and aroA Genes of Methicillin-Resistant Staphylococcus aureus Strains Isolated From Nasal Samples in Western Iran. Jundishapur J Microbiol. 2016; 9: e26460.

Masoomi asl H ZS, Majidpoor A,Nateghian AR, Afhami SH, Rahbar AR,et al. National guidline of nosocomial infections survilance. Tehran: Center for communicable Disease Control, Ministry of Health, 2007.

Magill SS, Hellinger W, Cohen J, et al. Prevalence of healthcare-associated infections in acute care hospitals in Jacksonville, Florida. Infection Control & Hospital Epidemiology. 2012; 33: 283-91.

Yallew WW, Kumie A and Yehuala FM. Point prevalence of hospital-acquired infections in two teaching hospitals of Amhara region in Ethiopia. Drug, healthcare and patient safety. 2016; 8: 71.

Ghashghaee A, Behzadifar M, Azari S, et al. Prevalence of nosocomial infections in Iran: A systematic review and meta-analysis. Medical journal of the Islamic Republic of Iran. 2018; 32: 48.

Cassini A, Plachouras D, Eckmanns T, et al. Burden of six healthcare-associated infections on European population health: estimating incidence-based disability-adjusted life years through a population prevalence-based modelling study. PLoS medicine. 2016; 13.

Becerra MR, Tantaleán JA, Suárez VJ, Alvarado MC, Candela JL and Urcia FC. Epidemiologic surveillance of nosocomial infections in a Pediatric Intensive Care Unit of a developing country. BMC pediatrics. 2010; 10: 66.

Khan HA, Baig FK and Mehboob R. Nosocomial infections: Epidemiology, prevention, control and surveillance. Asian Pacific Journal of Tropical Biomedicine. 2017; 7: 478-82.

Weinstein RA, Gaynes R, Edwards JR and System NNIS. Overview of nosocomial infections caused by gram-negative bacilli. Clinical infectious diseases. 2005; 41: 848-54.

Hormozi SF, Vasei N, Aminianfar M, Darvishi M and Saeedi AA. Antibiotic resistance in patients suffering from nosocomial infections in Besat Hospital. European journal of translational myology. 2018; 28.

Khan HA, Ahmad A and Mehboob R. Nosocomial infections and their control strategies. Asian pacific journal of tropical biomedicine. 2015; 5: 509-14.

Scherbaum M, Kösters K, Mürbeth RE, et al. Incidence, pathogens and resistance patterns of nosocomial infections at a rural hospital in Gabon. BMC infectious diseases. 2014; 14: 124.

Allegranzi B, Nejad SB, Combescure C, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. The Lancet. 2011; 377: 228-41.

Blot K, Hammami N, Blot S, Vogelaers D and Lambert M-L. Seasonal variation of hospital-acquired bloodstream infections: A national cohort study. Infection Control & Hospital Epidemiology. 2021: 1-7.

Chen Y, He Y, Zhang W, et al. Pathogenic characteristics of nosocomial infections in patients with cerebrovascular diseases and characteristics and treatment of pathogenic bacteria in different seasons. Journal of Infection and Public Health. 2020; 13: 800-5.

Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC and Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Annals of internal medicine. 2007; 147: 573-7.

Garner JS, Jarvis WR, Emori TG, Horan TC and Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988; 16: 128-40.

McGrath EJ and Asmar BI. Nosocomial infections and multidrug-resistant bacterial organisms in the pediatric intensive care unit. The Indian Journal of Pediatrics. 2011; 78: 176-84.

Schmier JK, Hulme-Lowe CK, Semenova S, et al. Estimated hospital costs associated with preventable health care-associated infections if health care antiseptic products were unavailable. ClinicoEconomics and outcomes research: CEOR. 2016; 8: 197.

Rafter N, Finn R, Burns K, et al. Identifying hospital-acquired infections using retrospective record review from the Irish National Adverse Events Study (INAES) and European point prevalence survey case definitions. Journal of Hospital Infection. 2019; 101: 313-9.

Labi A, Obeng-Nkrumah N, Owusu E, et al. Multi-centre point-prevalence survey of hospital-acquired infections in Ghana. Journal of Hospital Infection. 2019; 101: 60-8.

Mohammadi M, Vaisi Raiegan A, Jalali R, Ghobadi A, Salari N and Barati H. The Prevalence of Nosocomial Infections in Iranian Hospitals. Journal of Babol University of Medical Sciences. 2019; 21: 39-45.

Behnke M, Aghdassi SJ, Hansen S and Pen A. The prevalence of nosocomial infection and antibiotic use in German hospitals. Deutsches Ärzteblatt International. 2017; 114: 851.

Murni IK, Duke T, Kinney S, Daley AJ and Soenarto Y. Reducing hospital-acquired infections and improving the rational use of antibiotics in a developing country: an effectiveness study. Archives of disease in childhood. 2015; 100: 454-9.

Choi J, Kwak Y, Yoo H, et al. Trends in the incidence rate of device-associated infections in intensive care units after the establishment of the Korean Nosocomial Infections Surveillance System. Journal of Hospital Infection. 2015; 91: 28-34.

Tomczyk-Warunek A, Blicharski T, Blicharski R, et al. Retrospective Study of Nosocomial Infections in the Orthopaedic and Rehabilitation Clinic of the Medical University of Lublin in the Years 2018–2020. Journal of Clinical Medicine. 2021; 10: 3179.

Bochicchio GV, Joshi M, Knorr KM and Scalea TM. Impact of nosocomial infections in trauma: does age make a difference? Journal of Trauma and Acute Care Surgery. 2001; 50: 612-9.

Schwab F, Gastmeier P, Hoffmann P and Meyer E. Summer, sun and sepsis—The influence of outside temperature on nosocomial bloodstream infections: A cohort study and review of the literature. PloS one. 2020; 15: e0234656.

Liu Y-X, Cao Q-M and Ma B-C. Pathogens distribution and drug resistance in patients with acute cerebral infarction complicated with diabetes and nosocomial pulmonary infection. BMC infectious diseases. 2019; 19: 603.

Cantón R, Huarte R, Morata L, et al. Determining the burden of infectious diseases caused by carbapenem-resistant gram-negative bacteria in Spain. Enfermedades Infecciosas y Microbiología Clínica. 2020.

Sang Y, Guo M and Huang J. Analysis on distribution of pathogenic bacteria and risk factors for nosocomial infection in patients in department of urology. 2017.

Chen Y-C, Lin C-F, Rehn Y-JF, et al. Reduced nosocomial infection rate in a neonatal intensive care unit during a 4-year surveillance period. Journal of the Chinese Medical Association. 2017; 80: 427-31.

van Vught LA, Klouwenberg PMK, Spitoni C, et al. Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis. Jama. 2016; 315: 1469-79.

Dhaliwal JK, El-Shafei AM, Al-Sharqi MR, Jothy KR, Vijayan U and Qadri A. Hospital morbidity due to post-operative infections in obstetrics & gynecology. Saudi medical journal. 2000; 21: 270-3.

Nashibi R, Khosravi A, Bakhtiary E and Shiravi M. Evaluation of risk factors and the epidemiological pattern of nosocomial infection after gynaecological surgery in Ahvaz Imam Khomeini Hospital during the period 2011–2016. Medical Studies/Studia Medyczne. 2020; 36: 26-30.

Zhao G-j, Li D, Zhao Q, et al. Incidence, risk factors and impact on outcomes of secondary infection in patients with septic shock: an 8-year retrospective study. Scientific reports. 2016; 6: 1-9.

Vincent J-L, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. Jama. 2009; 302: 2323-9.

Izadi N, Eshrati B, Etemad K, Mehrabi Y and Hashemi-Nazari S-S. Rate of the incidence of hospital-acquired infections in Iran based on the data of the national nosocomial infections surveillance. New Microbes and New Infections. 2020; 38: 100768.

Chen Y, Zhao J, Shan X, et al. A point-prevalence survey of healthcare-associated infection in fifty-two Chinese hospitals. Journal of Hospital Infection. 2017; 95: 105-11.

Tuomi T, Pasanen A, Leminen A, Bützow R and Loukovaara M. Incidence of and risk factors for surgical site infections in women undergoing hysterectomy for endometrial carcinoma. Acta obstetricia et gynecologica Scandinavica. 2016; 95: 480-5.

Elshami M, Bottcher B, Awadallah I, et al. Determinants of surgeons’ adherence to preventive intraoperative measures of surgical site infection in Gaza Strip hospitals: a multi-centre cross-sectional study. BMC surgery. 2020; 20: 21.

Othman AA and Abdelazim MS. Ventilator-associated pneumonia in adult intensive care unit prevalence and complications. The Egyptian Journal of Critical Care Medicine. 2017; 5: 61-3.