Factors affected outcome of Leptospirosis in Mukdahan hospital

Abstract

Background: Leptospirosis is an important zoonotic disease of worldwide distribution, including Thailand. There were no studies about Leptospirosis in Mukdahan hospital. We, therefore, investigated the factors affected outcome of Leptospirosis in Mukdahan hospital.

Materials and Methods: This is a retrospective study of the confirmed Leptospirosis, older than 15 years, who were admitted in Mukdahan hospital between 1 January 2015 to 31 December 2022. All clinical characteristics and laboratory data were analyzed.

Results: The confirmed Leptospirosis were 93 patients, most of the patients were male (84.90 %), age between 41-60 ปี (48.40%). Most of the patients had clinical improvement (90.30%). The mortality rate was 9.70 %.The factors affected outcome of Leptospirosis in Mukdahan hospital were age (p=0.04), respiratory failure with mechanical ventilator support (p=0.00), shock (p=0.00), hemoglobin level (p=0.01) and pulmonary hemorrhage (p=0.00). The multivariate linear regression model was developed with an R² of 0.583 (p <0.05). Age, respiratory failure with mechanical ventilator support and pulmonary hemorrhage were the significant predictors (p<0.05).

Conclusion: Knowing the factors affected outcome of the disease earlier would be able to monitoring and management for reduce the mortality rate of Leptospirosis.