Monocyte distribution width (MDW) as a predictive value on sepsis in patient’s admitted to Mukdahan Hospital

Abstract

Objectives: To study the sepsis predictiveness of the monocyte distribution width (MDW) value in bacterial sepsis patients admitted at Mukdahan hospital

Materials and Methods: A retrospective analytic study was performed. Data collections of Hemoculture and complete blood count of bacterial sepsis patients and control group were collected between February to June 2023, Three sample groups were: bacterial sepsis patients, Patients whose Hemoculture results were No growth. and control group, 76, 433 and 140 respectively. Statistical analysis was performed: percentage, mean, standard deviation, Median, Independent T-test, Mann-Whitney U test, Receiver Operating Characteristic curve.

Results: The study found that the proportion of patients with bacterial sepsis was slightly more male than female, accounting for 59.2 and 40.8%, respectively. mean age was 61.8±16.5 years. Most of them were infected with gram negative bacteria, up to 73.7 %. Third most common gram negative bacteria were Escherichia coli, Burkholderia pseudomallei and Klebsiella pneumoniae, accounting for 19.7, 15.8 and 11.8 %, respectively. Monocyte distribution width (MDW), Mean Monocyte volume (MMoV) and Monocyte Sepsis Index (MoSI) were 28.5±5.8, 190.1±15.9 and 54.6±13.3, Higher than the control group was statistically significant (p value <0.001). Burkholderia pseudomallei had average MDW values ​​of 28.4±5.6, When cut off value of MDW, MMoV, MoSI at 24.2, 181.5 and 41.7 were analyzed; sensitivity of 78.9, 72.4 and 85.5 %, Specificity of 96.4, 96.4 and 95.0 %, area under curve of 0.956, 0.909 and 0.964 respectively, in predicting sepsis.

Conclusions: Consideration of appropriate cut off values ​​of MDW, MMoV, and MoSI along with clinical data will help predict bacterial sepsis patients. The MDW and MoSI are more effective for predicting sepsis than MMoV