Risk Factors Associated with Mortality from Blood Stream Infection at Mukdahan Hospital
Keywords:
blood stream infection, mortality rate, risk factorAbstract
Objectives: To determine clinical characteristics, treatment and risk factors associated with mortality of blood stream infection patients.
Methods: A retrospective cohort study of adult patients diagnosed blood stream infection (BSI) who were hospitalized at Mukdahan hospital from October 1, 2020 to September 30, 2021. Medical records were reviewed and data were analyzed
Results: In total 261 medical records were reviewed. Of these 132 (50.6%) were male and mean age (+SD) was 63.2 (+16.4) years. Mortality rate was 17.6% (45/261). Underlying disease were identified in 204 (78.2%) cases. Blood culture were positive for Gram negatives bacteria 176 (67.4%) cases. Ninety-one cases (34.9%) met criteria of septic shock. Antibiotic treatment initiated within 1 hour after sepsis diagnosed and appropriate antibiotic in 24 hours were 176 (67.4%) and 246 (94.2%) cases respectively. Factor associated with increase mortality was cardiovascular failure.
Conclusions: Mortality rate of blood stream infection was high. Factor associated with increase mortality was cardiovascular failure.
References
World Health Organization. Global health estimates 2016: disease burden by cause, age, sex, by country and by region, 2006-2016. WHO. [Internet]. 2018 [cited 2019 Sep 7]. Available from: http://www.who.int/healthinfo/global_burden_disease/estimates/en/index1
Rhee C, Dantes R, Ebstein L, Murphy DJ, Seymour CW, Iwashyna TJ, et al. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014. JAMA.2017; 318(13): 1241-1249. doi:10.101/jama.2017.13836.
สำนักงานปลัดกระทรวงสาธารณสุข.อัตราตายผู้ป่วยติดเชื้อในกระแสเลือดแบบรุนแรงชนิด community-acquired เขตสุขภาพที่ 10. [อินเทอร์เนท]. 2565. [เข้าถึงเมื่อ 1 พ.ย. 2565]. เข้าถึงได้จาก: https://mdh.hdc.moph.go.th/hdc/reports
Singer M, Deutschman CS, Seymour CW, Shakar-Hari M, Annane D, Bauer M, et al. The third international concensus definitions of sepsis and septic shock (Sepsis-3). JAMA. 2016; 315(8): 801-810. doi: 10.1001/jama.2016.0287
Marik PE, Taeb AM. SIRS, qSOFA and new sepsis definition. J Thorac Dis. 2017;9(4): 943-945. doi: 10.21037/jtd.2017.03.125
Wang C, Xu R, Zeng Y, Zhao Y, Hu X. A comparison of qSOFA, SIRS and NEWS in predicting the accuracy of mortality in patients with suspected sepsis: A meta-analysis. PLoS ONE. 2022; 17(4): e0266755. https://doi.org/10.1371/journal.pone.0266755
Hantrakun V, Somayaji R, Teparrukkul P, Boonsri C, Rudd K, Day NPJ, et al. Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-sepsis). PLoS ONE. 2018; 13(9): eo204509. https://doi.org/10.1371/journal.pone.0204509
ลัลธริตา เจริญพงษ์, กิตติศักดิ์ ผลถาวรกุลชัย. อุบัติการณ์และปัจจัยเสี่ยงที่มีผลต่อการเสียชีวิตของผู้ป่วยติดเชื้อในกระแสโลหิตที่รับไว้รักษาในโรงพยาบาลเจ้าพระยายมราช. วารสารแพทย์เขต 4-5. 2563; 39(4): 542-560.
Conn JR, Catchpoole EM, Runnegar N, Mapp SJ, Markey KA. Low rates of antibiotic resistance and infectious mortality in a cohort of high-risk hematology patients: A single center, retrospective analysis of blood stream infection. PLoS ONE. 2017; 12(5): e0178159. https://doi.org/10.1371/journal.pone.0178059
Lueangarun S, Leelarusamee A. Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: A retrospective study. Interdiscip Perspect Infect Dis. 2012; 2012:765205. doi: 10.1155/2012/765205
Kanoksil M, Jatapai A, Peacock SJ, Limmathurotsakul D. Epidemiology, microbiology and mortality associated with community-acquired bacteremia in Northeast Thailand: A multicenter surveillance study. PLoS ONE. 2013; 8(1): e5471. doi: 10.1371/journal.pone.0054714
นิตยา อินทราวัฒนา. โรคติดเชื้อในโรงพยาบาลและสถานการณ์การดื้อยา. Journal of Medicine and Health Sciences. 2015;22(1): 81-92
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Nakhonphanom Hospital Journal

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
- บทความที่ได้รับการตีพิมพ์ถือเป็นลิขสิทธิ์ของ โรงพยาบาลนครพนม
- ข้อความหรือข้อคิดเห็นต่างๆ เป็นของผู้เขียนบทความนั้นๆ ไม่ใช่ความเห็นของกองบรรณาธิการ