Perioperative Complications of Colonoscopy Performed with Total Intravenous Anesthesia and Oral Sodium Phosphate for Bowel Preparation in Chumphae Hospital
Keywords:
Perioperative complication, Colonoscopy, Sodium phosphate, Total intravenous anesthesia, Hypokalemia, Duration of procedure, Anesthesia serviceAbstract
Objective: Colonoscopy is a gold standard procedure for colorectal cancer screening, thereby helping to reduce mortality. However, the procedure is allied with a higher incidence of complications. This study aimed to investigate colonoscopy complications and their associated factors, which have an impact on anesthesiology services.
Materials & Methods: This was a retrospective descriptive study conducted at Chumphae Hospital on a total of 334 patients who underwent colonoscopy between July 1, 2020 and June 30, 2021. Data were subjected to descriptive statistics, and univariate and multiple logistic regression analyses.
Results: The complications were revealed in 47.9% of the patients. Hypokalemia was the major adverse effect in 39.52% followed by cardiac arrhythmia (17.96%), hypotension (17.37%), and colonic perforation (0.3 %). The factors associated with complications were female (OR 2.54, p<0.01, CI=1.50-4.29), age (OR 1.03, p=0.02, CI=1.00-1.06), lower gastrointestinal bleeding (OR 2.93, p=0.01, CI=1.26-6.80), Potassium level before receiving sodium phosphate (OR 0.40, p<0.01, CI = 0.21-0.75), duration of procedure ( OR 1.02. , p=0.04, CI=1.00-1.04), and colonic polyp (OR 2.41, p<0.01, CI =1.25-4.64). Hypotension in colonoscopy patients was associated with stroke (OR 19.43, p=0.03, CI=1.30-288.56) whereas cardiac arrhythmia was linked to not receiving IV fluid containing potassium chloride (OR 0.47, p-value 0.02, CI = 0.24-0.91)
Conclusion: A large number of complications were observed from the colonoscopy, of which hypokalemia was the most common followed by arrhythmias and hypotension. Those with risk factors including females, elderly, colonic polyps, lower gastrointestinal tract bleeding, and stroke should be monitored for complications. In addition, the procedure should take no more than 30 minutes, and the patient should receive saline containing potassium chloride before undergoing colonoscopy.
References
Colorectal cancer statistics [internet]. WCRF International. [cited 2022 April 28]. Available at: https://www.wcrf.org/cancer-trends/colorectal-cancer-statistics/
ทะเบียนมะเร็ง 2563 [internet]. [cited 2022 April 28]. Available at: https://www.nci.go.th/e_book/hosbased_2563/index.html
Doubeni CA, Corley DA, Quinn VP, Jensen CD, Zauber AG, Goodman M, et al. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study. Gut [internet]. 2016 [cited 2022 April 28]; Available at: https://dash.harvard.edu/handle/1/35982042
Amornyotin S. Colonoscopy: anesthesia consideration. Med Time. 2013;15:17–20.
Whitlock EP, Lin JS, Liles E, Beil TL, Fu R. Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149(9):638–58.
Wernli KJ, Brenner AT, Rutter CM, Inadomi JM. Risks Associated With Anesthesia Services During Colonoscopy. Gastroenterology. 2016;150(4):888–94.
Amornyotin S. Complication Rate of Propofol-Based Deep Sedation for Colonoscopy in Marked Obesity Patients. J Gastroenterol Hepatol Res. 2015;4(8):1734–8.
Cotton PB, Eisen GM, Aabakken L, Baron TH, Hutter MM, Jacobson BC, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71(3):446–54.
Reumkens A, Rondagh EJA, Bakker CM, Winkens B, Masclee AAM, Sanduleanu S. Post-Colonoscopy Complications: A Systematic Review, Time Trends, and Meta-Analysis of Population-Based Studies. Am J Gastroenterol. 2016;111(8):1092–101.
ASGE Standards of Practice Committee, Fisher DA, Maple JT, Ben-Menachem T, Cash BD, Decker GA, et al. Complications of colonoscopy. Gastrointest Endosc. 2011;74(4):745–52.
Bujang MA, Sa’at N, Sidik TMITAB, Joo LC. Sample Size Guidelines for Logistic Regression from Observational Studies with Large Population: Emphasis on the Accuracy Between Statistics and Parameters Based on Real Life Clinical Data. Malays J Med Sci MJMS. 2018;25(4):122–30.
Assumptions of Logistic Regression [internet]. Statistics Solutions. [cited 10 May 2022]. Available at: https://www.statisticssolutions.com/free-resources/directory-of-statistical-analyses/assumptions-of-logistic-regression/
Beloosesky Y, Grinblat J, Weiss A, Grosman B, Gafter U, Chagnac A. Electrolyte Disorders Following Oral Sodium Phosphate Administration for Bowel Cleansing in Elderly Patients. Arch Intern Med. 2003;163(7):803–8.
Castro D, Sharma S. Hypokalemia. in: StatPearls [internet]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Aug 31]. Available at: http://www.ncbi.nlm.nih.gov/books/NBK482465/
Lv L, Shao YF, Zhou YB. The enhanced recovery after surgery (ERAS) pathway for patients undergoing colorectal surgery: an update of meta-analysis of randomized controlled trials. International journal of colorectal disease. 2012 Dec;27(12):1549-54.
Rostom A, Jolicoeur E, Dubé C, Grégoire S, Patel D, Saloojee N, et al. A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy. Gastrointest Endosc. 2006;64(4):544–52.
Manta R, Tremolaterra F, Arezzo A, Verra M, Galloro G, Dioscoridi L, et al. Complications during colonoscopy: prevention, diagnosis, and management. Tech Coloproctology. 2015;19(9):505–13.
Cardin F, Minicuci N, Campigotto F, Andreotti A, Granziaera E, Donà B, et al. Difficult colonoscopies in the propofol era. BMC Surg. 2012;12(1):S9.
Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Gastrointest Endosc. 2011;74(4):885–96.
Lhewa DY, Strate LL. Pros and cons of colonoscopy in management of acute lower gastrointestinal bleeding. World J Gastroenterol WJG. 2012;18(11):1185–90.
Sirikurnpiboon S. Colonoscopic Perforation and Its Management at a Tertiary Care Hospital. Thai J Surg. 2021;42(3):76–82.
Arana-Arri E, Imaz-Ayo N, Fernández MJ, Idigoras I, Bilbao I, Bujanda L, et al. Screening colonoscopy and risk of adverse events among individuals undergoing fecal immunochemical testing in a population-based program: A nested case-control study. United Eur Gastroenterol J. 2018;6(5):755–64.
Kim SY, Kim HS, Park HJ. Adverse events related to colonoscopy: Global trends and future challenges. World J Gastroenterol. 2019;25(2):190–204.
Sneyd JR, Absalom AR, Barends CRM, Jones JB. Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. Br J Anaesth. 12022;128(4):610–22.
Jung YS, Jee Y, Im E, Kim M ho, Moon CM. Bowel Preparation and Subsequent Colonoscopy Is Associated with the Risk of Atrial Fibrillation: A Population-Based Case-Crossover Study. J Pers Med. 2022;12(8):1207.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Nakhonphanom Hospital Journal

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
- บทความที่ได้รับการตีพิมพ์ถือเป็นลิขสิทธิ์ของ โรงพยาบาลนครพนม
- ข้อความหรือข้อคิดเห็นต่างๆ เป็นของผู้เขียนบทความนั้นๆ ไม่ใช่ความเห็นของกองบรรณาธิการ