Developing guidelines for adjusting the appropriate dose of injectable antibiotics at Nakhon Phanom Hospital

Abstract

Objective: So that, the patient receives the drug in a dose that is appropriate for the renal function It can help reduce costs of antibiotic injection

Materials and methods: Retrospective data were collected from the reporting system for the use of injectable antibiotics in inpatient admitted at Nakhon Phanom Hospital. The new and old system segmentation model is descriptive of the use of injectable antibiotics. Comparison of the number of appropriate injectable antibiotics in patients with chronic kidney disease. Compare the cost of injectable antibiotics before and after antibiotic adjustments in patients with chronic kidney disease.

Results: Data collection using 17 injectable antibiotics for inpatients who come to the service at Nakhon Phanom Hospital from 1 January 2017–30 September 2021. The dose adjustment of injectable antibiotics after the new system was adjusted, compared with the old system accounted for 77.18% and 65.99% respectively, with significant differences. (P-Value <0.001). After implementation of the system, 3 drugs with the highest rate of inappropriate dosage adjustment were ceftazidime injection 1 g, Amoxicillin+Clavulonic acid. injection and Meropenem injection 1 g. Proportion of loss resulting from inappropriate dosage adjustment decreased from 24.15% to 3.01%.

Conclusion: This study was found that adjustment of injectable antibiotics after adaptation. The new system making the use of antibiotics more appropriate and reduce drug costs of antiobiotic injections.