The effectiveness to reduce the occurrence of persistent pulmonary hypertension of the newborn of Nakhonphanom hospital’s protocol for newborn with meconium aspiration syndrome and meconium stained amniotic fluid

Abstract

Objective: To study the effectiveness of protocol for persistent pulmonary hypertension of the newborn in meconium aspiration syndrome and meconium stained amniotic fluid. By comparing the rate of occurrence of persistent pulmonary hypertension of the newborn in meconium aspiration syndrome and meconium stained amniotic fluid before and after using the protocol for Persistent pulmonary hypertension of the newborn at Nakhonphanom hospital.

Materials and methods: This research was retrospective interrupted time. The sample used in the research is meconium aspiration syndrome (MAS) and meconium stained amniotic fluid (MSAF) for treatment and delivery in Nakhonphanom hospital between August 2015 and May 2017. The total number of 302 patients were divided into 2 groups, namely MAS patients who did not receive any guideline care between August 2015 and January 2018, there were 203 cases and a cohort of MAS infant patients, MSAF who received guideline care. between February 2018 and May 2019, 99 cases.

Results: It was found that the MAS treatment group had a lower incidence of PPHN to 0.73 times (p=0.604), 0.72 times the incidence of PPHN (p=0.587) and 0.25 times the mortality (p =0.200)

Conclusion: The research results the incidence of PPHN in Nakhonphanom hospital had trend to reduce after implement the MAS and MSAF guideline. However, the applying of this guideline to patients with risk of persistent pulmonary hypertension of the newborn may provide particularly awareness.