The effectiveness of using the protocol for monitoring incidence of Metformin Associated Lactic Acidosis in diabetic mellitus patients at Nakhonphanom Hospital

Abstract

Objective : To study the effectiveness of using the protocol for monitoring incidence of Metformin Associated Lactic Acidosis in diabetic mellitus patients at Nakhonphanom Hospital.

Materials and methods : This study was quasi-experimental research. The sample were diabetic patients that treated with metformin in Nakhonphanom Hospital from 1 October 2017-30 September 2020. The research instruments consisted protocol for monitoring incidence of metformin associated lactic acidosis, adverse drug event record form, new case metformin counseling record form, drug related problem record form. Data were analyzed by frequency, percentage and Chi-square test.

Result : The results in Diabetic mellitus patients that received metformin 5,073 cases found that 1) Screening order of metformin by pharmacist found 97 orders were contraindication of metformin and 44 orders were too high dose of metformin after consulted there were stopped metformin 92 orders (94.8%) and decrease dose of metformin 40 orders (90.9%) 2) Incidence of metformin associated lactic acidosis after using the protocol was significantly lower than before using the protocol (p<0.05).

Conclusion : The results of the research show that protocol for monitoring incidence of metformin associated lactic acidosis can reduce incidence of metformin associated lactic acidosis. And should expand this protocol to other hospital in Nakhonphanom province.