Comparing Efficacy of Combined Intense Pulsed Light Therapy and Low-level Light Therapy Versus Intense Pulsed Light for the Treatment of Dry Eye Disease: A Retrospective Study
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摘要
Introduction: Dry eye disease is a prevalent condition that impacts millions of individuals globally, with meibomian gland dysfunction (MGD) being a significant contributor to the development of this condition. In recent years, intense pulsed light (IPL) and low-level light therapy (LLLT) have emerged as promising treatments for MGD-related dry eye disease. Several studies have reported that a combined therapy of IPL with LLLT is effective in treating MGD patients. However, to date, there is a lack of research comparing the efficacy of IPL alone versus IPL in combination with LLLT in the treatment of dry eye patients.
Purpose: To compare the efficacy of Intense Pulsed Light therapy combined with Low-Level Light therapy Versus Intense Pulsed Light for the treatment of dry eye disease
Study design: Retrospective single-center clinical study
Materials and Methods: Patients presenting with a dry eye disease (DED) with MGD and having received treatment with IPL or IPL with LLLT at Thammasat University Hospital between February 2023 and November 2023 were included. The single IPL session and combined IPL and LLLT session was performed once weekly over 3 weeks. The end point was the mean difference of DEQ-5 score between baseline (0-14 days before the first session of the treatment) and 2 weeks after the last session. Data collection was done retrospectively. Statistical analysis was done using STATA 16.0.
Results: 51 patients were included (25 patients from IPL group, 26 patients from IPL with LLLT group). DEQ-5 score significantly decreased after the single IPL treatment and the combined IPL with LLLT treatment (P < 0.001). Patients in the combined IPL with LLLT group showed significant improvement in DEQ-5 score compared with the single IPL group (-10.2 ± 3.1 vs -7.8 ± 2.1, P < 0.05). There was no adverse effect reported in both groups.
Conclusions: Both IPL and IPL with LLLT were safe and effective in improving ocular discomfort symptoms in MGD-related dry eye disease. However, the combined IPL with LLLT determined a greater improvement in symptoms.
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