Acquired color vision deficiency in Vietnamese patients with primary open angle glaucoma
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Abstract
Aim: To study acquired color vision deficiency (ACVD) in Vietnamese patients with primary open angle glaucoma (POAG).
Methods: Cross-sectional descriptive study on 51 eyes of 27 patients with POAG presenting to the Vietnam National Institute of Ophthalmology. Color vision defects were assessed using Farnsworth-Munsell 100 Hue Test. Data were matched to visual field defects on the Humphrey Visual Analyzer (HVFA) and optic nerve analysis on optical coherence tomography (OCT).
Results: 48/51 eyes had color vision defects, with average total error score (TES) of 128.78 ± 117.93. Of these44 of 48 eyes manifested a tritan color vision defect. We found an inverse correlation between TES and mean deviation (MD) on the HVFA (Spearman's Rho Testing, r = -0.238, p < 0.05). The severity of color vision deficiency was correlated to average retinal nerve fiber layer (RNFL) thickness on OCT. There was a high degree of interocular correlation in TES at the FM100Hue; however, asymmetry was noted in patients having different clinical stages of glaucoma between eyes. (Wilcoxon signed-rank test, z = -2.667, p < 0.01). 19.6% of eyes had ACVD without manifest visual field defect on the HVFA and 7.6% eyes had ACVD without decreased RNFL thickness on OCT.
Conclusion: We found a high prevalence of acquired color vision deficiency in our cohort of patients with POAG, suggesting ACVD may be an important finding in POAG.
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References
Mollon, J.D., Color vision: Opsins and options. Proceedings of the National Academy of Sciences, 1999. 96(9): p. 4743-4745.
Simunovic, M.P., Colour vision deficiency. Eye (Lond), 2010. 24(5): p. 747-55.
Simunovic, M.P., Acquired color vision deficiency. Survey of Ophthalmology. 61(2): p. 132-155.
Fairchild, M.D., Human Color Vision, in Color Appearance Models. 2013, John Wiley & Sons, Ltd. p. 1-37.
Pacheco-Cutillas, M., D.F. Edgar, and A. Sahraie, Acquired colour vision defects in glaucoma-their detection and clinical significance. Br J Ophthalmol, 1999. 83(12): p. 1396-402.
Cho, N.C., et al., Selective loss of S-cones in diabetic retinopathy. Arch Ophthalmol, 2000. 118(10): p. 1393-400.
Percival, K.A., P.R. Martin, and U. Grunert, Organisation of koniocellular-projecting ganglion cells and diffuse bipolar cells in the primate fovea. Eur J Neurosci, 2013. 37(7): p. 1072-89.
Vingrys, A.J. and P.E. King-Smith, A quantitative scoring technique for panel tests of color vision. Invest Ophthalmol Vis Sci, 1988. 29(1): p. 50-63.
Mills, R.P., et al., Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol, 2006. 141(1): p. 24-30.
Fristrom, B., Colour contrast sensitivity in ocular hypertension. A five-year prospective study. Acta Ophthalmol Scand, 2002. 80(2): p. 155-62.
Misiuk-Hojlo, M., et al., [Clinical advantages of colorimetric exploration in the early diagnosis of glaucomatous neuropathy]. J Fr Ophtalmol, 2004. 27(8): p. 891-6.
Papaconstantinou, D., et al., Acquired color vision and visual field defects in patients with ocular hypertension and early glaucoma. Clin Ophthalmol, 2009. 3: p. 251-7.
Beirne, R.O., L. McIlreavy, and M.B. Zlatkova, The effect of age-related lens yellowing on Farnsworth-Munsell 100 hue error score. Ophthalmic Physiol Opt, 2008. 28(5): p. 448-56.
Weinreb, R.N., P.L. Kaufman, and N. Gupta, Koniocellular pathway damage in glaucoma.
Kolb, H., Simple Anatomy of the Retina by Helga Kolb.
Yamazaki, Y., et al., Correlation between color vision and highest intraocular pressure in glaucoma patients. Am J Ophthalmol, 1988. 106(4): p. 397-9.
Drance, S.M., et al., Acquired color vision changes in glaucoma: Use of 100-hue test and pickford anomaloscope as predictors of glaucomatous field change. Archives of Ophthalmology, 1981. 99(5): p. 829-831.
Flammer, J. and S.M. Drance, Correlation between color vision scores and quantitative perimetry in suspected glaucoma. Arch Ophthalmol, 1984. 102(1): p. 38-9.
Yamazaki, Y., et al., Correlation of blue chromatic macular sensitivity with optic disc change in early glaucoma patients. Jpn J Ophthalmol, 2002. 46(1): p. 89-94.
Airaksinen, P.J., et al., Color vision and retinal nerve fiber layer in early glaucoma. Am J Ophthalmol, 1986. 101(2): p. 208-13.
Polo, V., et al., Correlation of functional and structural measurements in eyes suspected of having glaucoma. J Glaucoma, 1999. 8(3): p. 172-6.