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Background: Nowadays, in large eye centers, two Fourier-domain optical coherence tomography (OCT) devices are often used in parallel to obtain optical coherence tomograph images of patients, especially retinal nerve fiber layer (RNFL) thickness analysis and central retinal image. Determining system stability and accuracy, as well as finding a correlation and a formula to unify measurement values of these 2 systems are essential to finding consensus in clinical practice.
Objectives: To evaluate measurement errors of Cirrus HD and Spectralis OCT system in analyzing optic nerve head and the correlation of the results from these two systems.
Methods: Cross-sectional study. Seventy-one eyes from 38 patients underwent RNFL thickness analysis by Cirrus HD system 3 times consecutively, which was repeated after 5 minutes rest. The whole procedure was then repeated using Spectralis system, after another period of 30 minutes rest. Measurement errors of each quadrant (superior, inferior, nasal and temporal) and the overall errors were analyzed. The correlation between measurement values of Cirrus HD and Spectralis system, as well as a formula to convert Spectralis measurement values into Cirrus HD values, was conducted.
Results: The overall measurement error of Spectralis system was significantly higher than that of Cirrus HD system (p=0.015). The measurement errors of Spectralis system were also significantly higher than those of HD system in inferior, nasal and temporal zone (p<0.05). In both systems, the measurement errors before and after 5 minutes rest did not differ significantly (p>0.05). There was a strong linear correlation between Spectralis and Cirrus HD measurement values (R=0.91, p<0.001).
Conclusion: Spectralis system has statistically higher measurement errors than Cirrus HD system, however the difference is less likely to have clinical meaning. Both systems could be used in parallel in clinical practice with acceptable consensus.
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