Evaluation of the Relationship between Serum TSH Receptor Antibody and Dry Eye Syndrome in Graves’ Disease: A Cross-sectional Study
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Abstract
Background: This study aimed to evaluate the relationship between serum TSH receptor antibody levels and dry eye syndrome in Graves' disease patients without graves’ orbitopathy.
Materials and Methods: This cross-sectional study encompassed 28 eyes of 14 individuals diagnosed with Graves’ disease. Serum TSH receptor antibodies were measured followed by dry eye parameters assessed via the OCULUS Keratograph® 5M specifically Non-Invasive Keratograph Break-Up Time, tear meniscus height, and redness score. Dry eye symptoms were assessed with OSDI score.
Results: The majority of Graves’ disease patients exhibit moderate severity of dry eye symptoms (Mean OSDI score = 25.05) and high TSH receptor antibody level (Mean TRAb level = 9.61). The TSH receptor antibody level shows a significant association primarily with the redness score (r = 0.410, p = 0.030). However, no significant correlations were observed between the TSH receptor antibody level and tear meniscus height, NIKBUT, or OSDI score.
Conclusion: In Graves’ disease patients without Graves orbitopathy, a correlation was observed between Serum TSH receptor antibody levels and the redness score. However, there was no correlation between TSH receptor antibody levels and other dry eye parameters or symptoms associated with dry eye syndrome.
Conflicts of Interest: no financial interest in any products or instruments mentioned in this study.
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