A Comparative Study of Pain Intensity in Patients Receiving Cooling Botulinum Toxin (BTX) and Non-cooling BTX
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Abstract
Objective: To compare pain intensity in the patients who receive both cooling Botulinum toxin (BTX) injections and non-cooling BTX injections around the periocular area.
Methods: A Prospective, randomized, single-blind controlled trial study of patients who had bilateral blepharospasm or bilateral hemifacial spasm between June 2021 and October 2022. Each patient received 10 points of BTX injections around the periocular area (randomized into 5 injection points each of cooling and non-cooling BTX respectively). A visual analog scale (VAS) was used to measure the pain intensity immediately after injection at each point. Main outcome measures: pain score and complication. cooling botox: 15-18℃, non-cooling botox: room temperature 25-27℃.
Results: A cohort of 11 patients received 55 points for cooling BTX injections and 55 points for non-cooling BTX injections. The mean pain score of the cooling BTX group was 1.91 ± 1.59, while the non- cooling BTX group had a mean pain score of 1.89 ± 1.59, the difference was not statistically significant (p = 0.887). The highest pain levels in both groups were at the upper eyelids and lower (mean pain score of 2.0).
Conclusion: There was no significant difference in the pain intensity and complication between cooling BTX and non-cooling BTX injections.
Conflicts of Interest: none
Article Details
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