Choroidal Thickness Evaluation in Central Serous Chorioretinopathy in Thammasat University Hospital

Main Article Content

kittichai akrapipatkul

Abstract

Abstract


Purpose: To establish a normative database of subfoveal choroidal thickness (CT) in normal eyes compared with central serous chorioretinopathy eyes (CSC) by using enhanced depth-imaging optical coherence tomography.


Methods: This cross-sectional, observational study was carried out on outpatients recruited from the Department of Ophthalmology, Faculty of Medicine, Thammasat University Hospital, Thailand, from November 2018 to June 2019. A total of 30 patients (30 eyes) was included (15 normal eyes of healthy patients, 15 central serous chorioretinopathy eyes). Subfoveal choroidal thickness was measured by enhanced depth-imaging optical coherence tomography. Subjects with systemic diseases and ocular diseases that may affect the choroidal vascular blood vessels were excluded.


Results: In CSC eyes, a mean of subfoveal choroidal thickness was 390.96±55.12 μm with a mean age of 46.13±10.70 years. 86.67% was male. In normal eyes, a mean of subfoveal choroidal thickness was 250.69±69.95 μm with a mean age of 60.07±11.91 years. 53.33% was female. Baseline axial length, autorefraction and BCVA showed no difference between two groups. Subgroup analysis of choroidal thickness in different age groups showed a mean of subfoveal choroidal thickness in CSC eyes was thicker than normal eyes in every age group. The age groups of 41-50, 61-70 and 71-80, subfoveal choroidal thickness in CSC eyes was thicker than normal eyes with statistical significance.


Conclusion: The mean subfoveal choroidal thickness was 390.96±55.12 μm and 250.69±69.95 μm in CSC eyes and normal eyes respectively in Thai population. The mean subfoveal choroidal thickness in CSC eyes was thicker than normal eyes significantly.


Keywords: choroidal thickness, central serous chorioretinopathy, enhanced depth-imaging optical coherence tomography

Article Details

Section
Original Study

References

1. Warrow DJ, Hoang QV, Freund KB (2013) Pachychoroid pigment epitheliopathy. Retina 33(8):1659–1672
2. ปรียานุช คุณทรงเกียรติ, ดิเรก ผาติกุศิลา. สเปคตรัมของโรคคอรอยด์หนาตัว.เชียงใหม่เวชสาร 2560;56(2)
3. Daruich A, MAtet A, Dirani A, Bousquet E, Zhao M, Farman N,et al. Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis. Prog Retin Eye res. 2015;48:82-118
4. Kitzmann AS, Pulido JS, Diehl NN, Hodge DO, Burke JP. e incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980– 2002. Ophthalmology 2008;115:169-73.
5. Chan W-M, Lai TY, Tano Y, Liu DT, Li KK, Lam DS. Photodynamic therapy in macular diseases of Asian populations: when East meets West. Jpn J Ophthalmol 2006;50:161-9.
6. Balo K, Mihluedo H. [Idiopathic central serous chorioretinopathy: two case reports observed in Togo]. Med Trop (Mars) 1996;56:381-3.
7. Desai UR, Alhalel AA, Campen TJ, Schi man RM, Edwards PA, Jacobsen GR. Central serous chorioretinopathy in African Americans. J Natl Med Assoc 2003;95:596.
8. Lehmann, M., Bousquet, E., Beydoun, T., Behar-Cohen, F., 2015. PACHYCHOROID: an inherited condition? Retina (Phila. Pa.) 35, 10e16.
9. Arora S, Pyare R, Sridharan P, Arora T, Thanker M, Ghosh B. Choroidal thickness evaluation of healthy eyes, central serous chorioretinopathy, and the fellow eyes using spectral domain optical coherence tomography in Indian population. Indian J Ophthalmology[Internet]. 2016;64(10);747
10. Yun C, Oh J, Han JY, Hwang SY, Moon SW, Huh K. Peripapillary choroidal thickness in central serous chorioretinopathy: Is choroid outside the macula also thick? Retina 2015;35:1860‐6
11. Yalcinbayir O, Gelisken O, Akova‐Budak B, Ozkaya G, Gorkem Cevik S, Yucel AA. Correlation of spectral domain optical coherence tomography findings and visual acuity in central serous chorioretinopathy. Retina 2014;34:705‐12
12. Kuroda S, Ikuno Y, Yasuno Y, Nakai K, Usui S, Sawa M, et al. Choroidal thickness in central serous chorioretinopathy. Retina 2013;33:302‐8
13. Kim SW, Oh J, Kwon SS, Yoo J, Huh K. Comparison of choroidal thickness among patients with healthy eyes, early age‐related maculopathy, neovascular age‐related macular degeneration, central serous chorioretinopathy, and polypoidal choroidal vasculopathy. Retina 2011;31:1904‐11
14. Maruko I, Iida T, Sugano Y, Ojima A, Sekiryu T. Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy. Retina 2011;31:1603‐8.
15. Imamura Y, Fujiwara T, Margolis R, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina 2009;29:1469‐73.
16. Chhablani J, Rao PS, Venkata A, Rao HL, Rao BS, Kumar U, et al. Choroidal thickness profile in healthy Indian subjects. Indian J Ophthalmol 2014;62:1060‐3.
17. Sanchez‐Cano A, Orduna E, Segura F, Lopez C, Cuenca N, Abecia E, et al. Choroidal thickness and volume in healthy young white adults and the relationships between them and axial length, ammetropy and sex. Am J Ophthalmol 2014;158:574‐83.e1.
18. Branchini LA, Adhi M, Regatieri CV, Nandakumar N, Liu JJ, Laver N, et al. Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral‐domain optical coherence tomography. Ophthalmology 2013;120:1901‐8.
19. Jirarat tanasopa, Pichai Panon, Nisa Hiranyachattada, et al. The normal choroidal thickness in southern Thailand. 2014;8: 2209-13.
20. Ding X, Li J, Zeng J, Ma W, Liu R, Li T, et al. Choroidal thickness in healthy Chinese subjects. Invest Ophthalmol Vis Sci 2011;52:9555‐60.
21. Li XQ, Larsen M, Munch IC. Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students. Invest Ophthalmol Vis Sci 2011;52:8438‐41.
22. AgawaT,MiuraM,IkunoY,MakitaS,FabritiusT,IwasakiT,etal. Choroidal thickness measurement in healthy Japanese subjects by three‐dimensional high‐penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2011;249:1485‐92.
23. ManjunathV,TahaM,FujimotoJG,DukerJS.Choroidalthickness in normal eyes measured using Cirrus HD optical coherence tomography. Am J Ophthalmol 2010;150:325‐9.e1.
24. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173‐6.
25. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009;147:811‐5.
26. R. (2000). Fundamentals of biostatistics(5th ed.). Duxbery: Thomson learning,308.
27. ฉลองสุข.ระพีพรรณ. การกำหนดขนาดตัวอย่าง (Sample Size). วารสารไทยไภษัชยนิพนธ์ Thai Bull Pharm Sci. 2007;4(1):1–19.