Comparison of cryopreserved amniotic membrane grafts versus dry amniotic membrane grafts combined with intraoperative mitomycin C for primary pterygium excision using fibrin glue technique

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Jirapone Supokawate


Objective: To compare the recurrence rate of cryopreserved amniotic membrane (cryo  AM) grafts and dry amniotic membrane (dry AM) grafts after primary pterygium excision combined with intraoperative mitomycin C (MMC) using fibrin glue technique at 1 year follow up.

Design: prospective randomized controlled trial

Methods: A prospective randomized controlled trial was conducted in 39 subjects with primary pterygium that were enrolled and randomized into 2 groups, 19 eyes in the cryo AM group, and 20 eyes in the dry AM group. In patients with primary pterygium underwent pterygium excision, 0.02% MMC was applied to the scleral bed.  Amniotic membrane was attached using the fibrin glue technique.  The measured outcome was recurrence rate at 1 year.

Results: The recurrence rate after pterygium excision with cryo AM and dry AM grafts were 5.26% and 5% respectively.  There was no significant difference in the recurrence rate between the 2 groups (p = 0.839).

Conclusion: This study provides preliminary evidence that dry AM grafts were effective as cryo AM grafts in adjunctive of pterygium excision to reduce the post operative recurrence.

Conflicts of interest: None


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Original Study


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