Incidence of Glaucoma in Ocular Hypertension patients post laser-assisted in situ keratomileusis (LASIK) treatment -

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Jirapone Supokawate


Objective: To report the incidence of optic nerve damage in patients with ocular hypertension (OHT) 4 years after LASIK treatment and to study the relationship of transient IOP rises during LASIK treatment to optic nerve damage and to determine potential risk factors for glaucoma progression in OHT patients after LASIK treatment.

Design: cohort retrospective study

Methods:  A cohort retrospective study review of 139 patients with OHT who underwent LASIK surgery at BMA hospital was performed from 2008 – 2012.  All patients were followed up for optic nerve damage for 4 years. Glaucoma progression was determined by using CTVF and OCT.  Cox proportional hazard model was used to determine potential risk factors such as age, IOP, CCT and VCD ratio.

Results:  Among 139 patients, 6 eyes of 6 patients (4.3%) developed POAG (95%CI: 09% to 7.7%), the incidence rate of POAG at 4 years was 2.9%. No glaucoma progression was found at 1 year after LASIK treatment. Age and IOP were significant risk factors for the development of glaucoma, (HR= 1.12, 1.91; p = 0.038, 0.025) respectively. 

Conclusion: The incidence of patients who developed POAG after LASIK at 4 years was low (4.3%) compared to the OHTS group at 5 years (9.5%, non-treatment group). LASIK does not increase the risk of OHT patients in developing glaucoma. Brief rises in IOP during Keratomileusis did not damage the optic nerve.  Age and IOP play the important roles in glaucoma progression for OHT patients.

Conflicts of interest: None


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