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Background: Melioidosis is a multi-system infectious disease which is endemic in Malaysia. Melioidosis causing localized ocular infection has rarely been reported. This study highlights the various ocular manifestations of Melioidosis in patients with positive serology for Burkholderia pseudomallei in Hospital Selayang.
Case Series: There were three patients in this series. All were immunocompetent, with no systemic evidence of infection. One case had unilateral disease; the other two were bilateral, with common presenting symptoms of pain, redness and blurring of vision.
All patients had positive serology for Burkholderia pseudomallei and were treated with intravenous ceftazidime and either oral sulfamethoxazole-trimethoprim (Bactrim) or oral cefuroxime for a minimum of two months.
Conclusions: Melioidosis can manifest as an ocular infection in both the anterior and posterior segments of the eye. The diagnosis is clinical in nature and early empirical therapy should be commenced whilst awaiting confirmatory serology results.
Conflict of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.
2. Currie BJ. Burkholderia pseudomallei and Burkholderia mallei: melioidosis and Glanders. 2015.
3. Singh M, Mahmood M. Melioidosis: the great mimicker. J Community Hosp Intern Med Perspect. 2017;7(4):245-7.
4. Kingsley PV, Leader M, Nagodawithana NS, Tipre M,
Sathiakumar N. Melioidosis in Malaysia: A Review of Case Reports. PLoS Negl Trop Dis. 2016;10(12):e0005182.
5. Yee KC, Lee MK, Chua CT, Puthucheary SD. Melioidosis, the great mimicker: a report of 10 cases from Malaysia. J Trop Med Hyg. 1988;91(5):249-54.
6. How SH, Ng KH, Jamalludin AR, Shah A, Rathor Y. Melioidosis in Pahang, Malaysia. Med J Malaysia. 2005;60(5):606-13.
7. Zueter A, Yean CY, Abumarzouq M, Rahman ZA, Deris ZZ, Harun A. The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a North-Eastern state of Malaysia: a fifteen-year review. BMC Infect Dis. 2016;16:333.
8. Kritsiriwuthinan K, Wajanarogana S, Choosang K, Homsian J, Rerkthanom S. Production and evaluation of recombinant Burkholderia pseudomallei GroEL and OmpA proteins for serodiagnosis of melioidosis. Acta Trop. 2018;178:333-9.
9. Lau SK, Sridhar S, Ho CC, Chow WN, Lee KC, Lam CW, et al. Laboratory diagnosis of melioidosis: past, present and future. Exp Biol Med (Maywood). 2015;240(6):742-51.
10. Chenthamarakshan V, Vadivelu J, Puthucheary SD. Detection of immunoglobulins M and G using culture filtrate antigen of Burkholderia pseudomallei. Diagn Microbiol Infect Dis. 2001; 39(1):1-7.
11. Inglis TJ, Rolim DB, Rodriguez JL. Clinical guideline for diagnosis and management of melioidosis. Rev Inst Med Trop Sao Paulo. 2006;48(1):1-4.