Antibacterial Activity of Mandelic Acid Against Klebsiellae Pneumonia

Authors

  • choedchai saehuan -
  • Chalisa Pinitchun
  • Peeti Yimsiri

Keywords:

Antibacterial activity, Mandelic acid, Klebsiellae pneumoniae, Skin infection

Abstract

Mandelic acid was a synthetic substance or naturally extracted substance for the purpose of antibacterial
treatment of skin infectionscaused by Staphylococcusaureus with minimum inhibition concentration of
2.50 mg/ml. There had been no reports about antibacterial activity of mandelic acid against Klebsiella pnemoniae.
This study investigated the antibacterial activity of mandelic acid against Klebsiella pnemoniae ATCC BAA-
1705 by disk diffusion method and broth macrodilution method for minimum inhibition concentration and
minimum bactericidal concentration according to Clinical and Laboratory Standards Institute. The results
showed that the diameter of inhibition zone of mandelic acid at 0, 0.0152, 0.0304, 0.0608 and 0.0912
mg/ml presented 6.00 ± 0.00 mm by disk diffusion methodwith interpretation of no antibacterial inhibition.
Minimum inhibition concentration and minimum bactericidal concentrationof mandelic acid displayed
2.50 mg/ml and 2.50 mg/ml by broth macrodilution method, respectively. In conclusion, there was no
antibacterial activity of mandelic acid against K. pneumoniae by disk diffusion methodbut there was
antibacterial activity of mandelic acid against K. pneumoniae by broth macrodilution method. Hence,
this preliminary data had been useful to studythe antibacterial activity of mandelic acid against
K. pneumoniaisolated from clinical specimens of patients with skin infections in the future.

References

Ahmed, M. I. (2012). Prevalence of nosocomial wound

infection among postoperativepatients and

antibiotics patterns at Teaching Hospital in Sudan.

North American Journal of Medical Sciences,

(1), 29-34.

Broberg, C. A., Palacios, M., & Miller, V. L. (2013).

Whole-genome draft sequences of three

multidrug-resistant Klebsiella pneumoniae strains

available from the American Type Culture

Collection. Genome Announcement, 1(3), e003

-13.

Clinical and Laboratory Standards Institute. (2009).

Methods for dilution antimicrobial susceptibility

for bacteria that growth aerobically (8th ed.).

Approved standard M7-A8. Wayne, PA, USA:

Clinical and Laboratory Standards Institute.

Clinical and Laboratory Standards Institute. (2009).

Performance standards for antimicrobial disk

susceptibility tests (10th ed.). Approved standard

M2-A10. Wayne, PA, USA: Clinical and Laboratory

Standards Institute.

Clinical and Laboratory Standards Institute. (2010).

Performance standards for antimicrobial

susceptibility testing. Nine-teenth informational

supplement. M100-S20. Wayne, PA, USA:

Clinical and Laboratory Standards Institute.

Enrico, G., Lucia, F., & Roberto, P. (2019). Dermabrasion

with non-ablative electrosurgery and peeling

with mandelic acid and lactoferrin in the

treatment of perioral wrinkles. Dermatology

Research,1(1), 1-5.

Findlay, J., Hamouda,A., Dancer, S.J., & Amyes,

S. G. B. (2012). Rapid acquisition of decreased

carbapenem susceptibility in a strain of Klebsiella

pneumoniae arising during meropenem therapy.

Clinical Microbiology and Infection, 18(2), 140-146.

Foerster, S., Unemo, M., Hathaway, L. J., Low, N., &

Althaus, C. L. (2016). Time-kill curve analysis

and pharmacodynamic modelling for in vitro

evaluation of antimicrobials against Neisseria

gonorrhoeae. BMC Microbiology, 16(1), 1-11.

Hussain, S., Rahim, J., & Farooqui, M. (2012). Studies of

binary complexes of metal ions with mandelicacid

by potentiometry.Chemistry Journal, 2(6), 206-209.

Jeon, J. M., Lee, H. I., Kim, S. G., Han, S. H., & So, J. S.

(2010). Differential inactivation of food poisoning

bacteria and Lactobacillus sp. by mandelic acid.

Food Science and Biotechnology, 19(3), 583-587.

Kamienny, F. M., Barr, M., , & Nagwekart, J. B. (1969).

Mutual inhibitory effect of (-)-mandelic acid and

certain sulfonamides on the kinetics of their urinary

excretion in humans. Journal of Pharmaceutical

Sciences, 58(11), 1318-1324.

Kaye, K. S., Petty, L. A., Shorr, A. F., & Zilberberg,

M. D. (2019). Current epidemiology, etiology,

and burden of acute skin infections in the United

States. Clinical Infectious Diseases,68, S193-199.

Mitrea, L., & Vodnar, D. C. (2019). Klebsiella

pneumonia-a useful pathogenic strain for

biotechnological purposes: Diols biosynthesis

under controlled and uncontrolled pH levels.

Pathogens,8(4), 293.

Motamedifar, M., Bazargani, A., Namazi, M. R, &

Sarai, H. S. E. (2014). Antimicrobial activity

of mandelic acid against methicillin-resistant

Staphylococcus aureus: a novel finding with

important practical implications. World Applied

Sciences Journal, 31(5), 925-929.

Nassif, X. Fournier, J. M., Arondel, J., & Sansonetti, P. J.

(1989). Mucoid phenotype of Klebsiellapneumoniae

is a plasmid-encoded virulence factor. Infection

and Immunity, 57(2), 546-552.

Patel, J. B., Tenover, F. C., Turnidge, J. D., & Jorgensen,

J. H. (2011). Susceptibility test methods: Dilution

and disk diffusion methods. In J. Versalovic,

(Ed.), Manual of clinical microbiology (10th ed.)

(pp.1122-1143). Washington, D.C., USA: ASM

Press.

Patil, S. B., Paramne, A., & Harsh, S. (2016). Antibiotic

susceptibility of woundisolates in plastic surgery

patients at a tertiary care centre. Indian Journal

of Plastic Surgery, 49(2), 198-205.

Stan, C. D., Stefanache, A., Tataringa, G., Dragan,

M., &Tuchilus, C. G. (2015). Microbiological

evaluation and preservative efficiency of new

mandelicacid derivatives in ointments. Farmacia,

(4), 577-580.

Taylor, M. B. (1999). Summary of mandelic acid for

the improvement of skin condition. COSMETIC

DERMATOLOGY -CEDAR KNOLLS-, 12(6),

-30.

Tsuji, A. (2002). Transporter-mediated drug interactions.

Drug Metabolism and Pharmacokinetics, 17(4),

-274.

Downloads

Published

2022-08-23

How to Cite

saehuan, choedchai, Pinitchun, C. ., & Yimsiri, P. . (2022). Antibacterial Activity of Mandelic Acid Against Klebsiellae Pneumonia. NU Journal of Nursing and Health Sciences, 16(2), 55–65. Retrieved from https://he01.tci-thaijo.org/index.php/NurseNu/article/view/254773