Antibacterial Activity of Mandelic Acid Against Klebsiellae Pneumonia
Abstract
Mandelic acid was a synthetic substance or naturally extracted substance for the purpose of antibacterial
treatment of skin infectionscaused by Staphylococcusaureus with minimum inhibition concentration of
2.50 mg/ml. There had been no reports about antibacterial activity of mandelic acid against Klebsiella pnemoniae.
This study investigated the antibacterial activity of mandelic acid against Klebsiella pnemoniae ATCC BAA-
1705 by disk diffusion method and broth macrodilution method for minimum inhibition concentration and
minimum bactericidal concentration according to Clinical and Laboratory Standards Institute. The results
showed that the diameter of inhibition zone of mandelic acid at 0, 0.0152, 0.0304, 0.0608 and 0.0912
mg/ml presented 6.00 ± 0.00 mm by disk diffusion methodwith interpretation of no antibacterial inhibition.
Minimum inhibition concentration and minimum bactericidal concentrationof mandelic acid displayed
2.50 mg/ml and 2.50 mg/ml by broth macrodilution method, respectively. In conclusion, there was no
antibacterial activity of mandelic acid against K. pneumoniae by disk diffusion methodbut there was
antibacterial activity of mandelic acid against K. pneumoniae by broth macrodilution method. Hence,
this preliminary data had been useful to studythe antibacterial activity of mandelic acid against
K. pneumoniaisolated from clinical specimens of patients with skin infections in the future.
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