Effects of Extravasation Prevention Practice Guideline on Extravasation in Patients with Cancer Undergoing Chemotherapy


  • Sureeporn Maneerat
  • Ampaporn Namvongprom
  • Nam-oy Pakdevong


Extravasation, Extravasation prevention practice guideline, Chemotherapy


This Post-Test Only Control Group Design study aimed to investigate the effects of Extravasation prevention practice guideline on Extravasation in patients with cancer receiving FOLFOX regimen chemotherapy. A purposive sampling of 70 patients admitted to ward 14 of Chulabhorn Hospital during August 2017 to July 2018 was recruited for this study. 44 patients in comparison group received a standard care, 26 patients in intervention group received evidence-based care. Extravasation was assessed and collected during a cycle of chemotherapy. Data were analyzed using descriptive statistics and Fisher's Exact test. The findings showed that 6 patients (13.64%) in the comparison group had grade 2 Extravasation injuries while there was none in the intervention group. Fisher's Exact test found that there was no difference between the two groups (p = .078). Replication of research and increasing the number of subjects is also suggested.


Download data is not yet available.


Avdal, E.U. & Aydinoglu, N. (2012 ). Extravasation of

vesicant / non- vesicant drugs and evidence - based

management. International journal of caring

sciences, 5(2), 191-202.

Benna, S.A., Boyle, C.O. & Holley, J. (2013). Extravasation

injuries in adults. ISRN Dermatology., 1-8.

Deery, P. & Laurie, A. (2009). Guidelines for prevention

and management of chemotherapy extravasation.

Surrey, West Sussex and Hampshire cancer

network NHS.

Fidalgo, J.A., Fabregat, L. G., Cervantes, A., Margulies,

A., Vidall, C. & Rolia, F. (2012). Management

of chemotherapy extravasation : ESMO-EONS

clinical practice guidelines. Annals of oncology,

, 68-73.

Gonzalez, T.(2013). Chemotherapy extravasation:

prevention, identification, management, and

documentation. Clinical Journal of Oncology

Nursing, 17, 61-66.

Kreidieh, F.Y., Moukadem, H.A. & Saghir,N.S. (2016).

Overview, prevention and management of

chemotherapy extravasation. World Journal of

Clinical Oncology, 7(1), 87-95.

Molas, F., Ayuso, E. & Oubina, F. (2015). Level of adherence

to an extravasation protocol over 10 years

in a tertiary care hospital. Clinical journal of

oncology nursing, 19, 25-30.

National Cancer Institute. (2015). Chemotherapy.

Retrieved 3 February 2017 from https://www.


Pico, B., Laczo, I., Szatmari, K., Bassam, A., Szabo, Z.,

Ocsai, H. & Csotye, J. (2013). Overview of

extravasation management and possibilities for

risk reduction based on literature data. Journal of

nursing education and practice, 3, 93-105.

Sakaida, E., Sekine, I., Iwasawa, S., Kurimoto, R., Uehara,

T., Ooka, Y., . . . Takiguchi, Y. (2014). Incidence,

risk factors and treatment outcomes of extravasation

of cytotoxic agents in an outpatient

chemotherapy clinic. Japanese Journal of

Clinical Oncology, 44, 168-171.

Sharp, S. (2015). Guideline for management of extravasation

of a cytotoxic agent or a monoclonal

antibody used in treatment of malignant disease.

Guideline for management of extravasation.

Stanley, A. (2011). Guideline for the management of

extravasation. Pan Birmingham cancer network

governance committee chair.

Wengstrom, Y., Foubert, J., Margulies, A., Roe, H. &

Bugeia, S. (2007). Extravasation guidelines 2007.

European Oncology Nursing Society clinical practice


WOSCON Cancer Nursing and Pharmacy Group. (2009).

Chemotherapy extravasation guideline. West of

Scotland Cancer Advisory Network Clinical Leads





How to Cite

Maneerat, S., Namvongprom, A., & Pakdevong, N.- oy. (2019). Effects of Extravasation Prevention Practice Guideline on Extravasation in Patients with Cancer Undergoing Chemotherapy. NU Journal of Nursing and Health Sciences, 13(1), 99–109. Retrieved from https://he01.tci-thaijo.org/index.php/NurseNu/article/view/189246