Collagen type III glomerulopathy: a case report and literature Review
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Abstract
Collagen type III glomerulopathy is a rare glomerular disease, characterized by abnormal accumulation of type III collagen fibrils within a mesangial matrix and subendothelial space of glomerulus. Diagnostic confirmation requires electron microscopy of renal tissue to demonstrate curved collagen fibrils. Because of no definite treatment, renal outcome is unfavorable in most studies. No antecedent study of collagen type III glomerulopathy has been conducted in Thailand. We here report a 65-year-old woman with chronic hepatitis B cirrhosis and hepatocellular carcinoma who developed nephrotic syndrome with renal insufficiency. Characteristic curved fibrils were demonstrated using electron microscopy. Treatment with prednisolone and cyclophosphamide was not completely successful; however, the patient still presented stable renal function for more than 2 years. We further reviewed the related literature regarding incidence, demographic data, clinical manifestations, treatment and clinical outcomes of collagen type III glomerulopathy.
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References
Dong J, Wei H, Han M, Guan Y, Wu Y, Li H. Collagen type III glomerulopathy: A case report and review of 20 cases. Exp Ther Med. 2015;10(4):1445-9.
Cohen AH. Collagen Type III Glomerulopathies. Adv Chronic Kidney Dis. 2012;19(2):101-6.
Alsaad KO, Edrees B, Rahim KA, Alanazi A, Ahmad M, Aloudah N. Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy. Saudi J Kidney Dis Transpl. 2017;28(4): 898-905.
Ferreira RD, Custodio FB, Guimaraes CS, Correa RR, Reis MA. Collagenofibrotic glomerulopathy: three case reports in Brazil. Diagn Pathol. 2009;4:33.
Kurien AA, Larsen CP, Cossey LN. Collagenofibrotic glomerulopathy. Clin Kidney J. 2015;8(5):543-7.
Duggal R, Nada R, Rayat CS, Rane SU, Sakhuja V, Joshi K. Collagenofibrotic glomerulopathy-a review. Clin Kidney J. 2012;5(1):7-12.
Fogo AB, Lusco MA, Najafian B, Alpers CE. AJKD Atlas of Renal Pathology: Type III Collagen Glomerulopathy. Am J Kidney Dis. 2017;69(6):e25-e6.
Yasuda T, Imai H, Nakamoto Y, Ohtani H, Komatsuda A, Wakui H, et al. Collagenofibrotic glomerulopathy: a systemic disease. Am J Kidney Dis. 1999;33(1):123-7.
Lusco MA, Chen YP, Cheng H, Dong HR, Najafian B, Alpers CE, et al. AJKD Atlas of Renal Pathology: Fibronectin Glomerulopathy. Am J Kidney Dis. 2017;70(5):e21-e2.
Mizuiri S, Hasegawa A, Kikuchi A, Amagasaki Y, Nakamura N, Sakaguchi H. A case of collagenofibrotic glomerulopathy associated with hepatic perisinusoidal fibrosis. Nephron. 1993;63(2):183-7.
Soni SS, Gowrishankar S, Nagarik AP, Barnela SR, De Padua M, Adikey GK, et al. Collagenofibrotic glomerulopathy in association with Hodgkin’s lymphoma. Saudi J Kidney Dis Transpl. 2011;22(1): 126-9.
Pizzo HP, Haas M, Puliyanda D. Collagen type III glomerulopathy. Kidney Int. 2018;93(6):1490.
Reddy MHK, Kumar ACV, Chandra VS, Praveen N, Kurien AA, Sangeetha B, et al. Collagenofibrotic Glomerulopathy. Indian J Nephrol. 2017;27(4):331-3.
Autio P, Oikarinen A, Melkko J, Risteli J, Risteli L. Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect. Br J Dermatol. 1994;131(5):660-3.
Suzuki T, Okubo S, Ikezumi Y, Ueno M, Nishi S, Saito K, et al. [Favorable course of collagenofibrotic glomerulopathy after kidney transplantation and questionnaire survey about the prognosis of collagenofibrotic glomerulopathy]. Nihon Jinzo Gakkai Shi. 2004;46(4):360-4.