Retrospective Study of Adenovirus Infections at Ramathibodi Hospital (2012-2022): Investigating Risk Factors through Nucleic Acid Amplification Testing (NAAT) in Virology Laboratory Diagnostics

Authors

  • Kingkan Rakmanee Faculty of Medicine, Ramathibodi Hospital, Mahidol University
  • Treewat Watthanachockchai Faculty of Medicine, Ramathibodi Hospital, Mahidol University
  • Manutsanun Boonyanuwat Faculty of Science, Chulalongkorn University
  • Sirapichaya Phlykaew Faculty of Science, Chulalongkorn University
  • Praphan Suksudej Clinical Laboratory of Medical Technology, Lab House Chonburi Co., Ltd.
  • Vorthunju Nakhonsri National Biobank of Thailand, National Science and Technology Development Agency
  • Wuttipong Jaihan Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi
  • Pichet Yutthanakarnwikom Faculty of Medicine, Ramathibodi Hospital, Mahidol University
  • La-Or Chailurkit Faculty of Medicine, Ramathibodi Hospital, Mahidol University

DOI:

https://doi.org/10.14456/dcj.2026.32

Keywords:

adenovirus, retrospective study, Ramathibodi hospital

Abstract

Human adenovirus (HAdV) has been identified as a significant causative agent of infection, affecting patients of all age demographics. The present retrospective study was conducted with the objective of investigating the association of risk factors with adenovirus infection. An analysis was conducted on data from the Virology Laboratory, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, from 2012 to 2022. The study included a total of 46,128 individuals. The study identified 2,348 infections (5.09%), with the highest number of infections (436, 9.86%) recorded in 2013. In particular, the infection rate was found to be higher in children under 12 years. The former group included toddlers (8.46%), preschoolers (9.17%), and school-aged children (6.11%), with the infection rate greather than for the newborn and infant being 3.92%. Correlation analysis was performed Multivariable logistic regression analysis revealed that toddlers (Adjusted OR=2.12, 95% CI=1.74-2.57), preschoolers (Adjusted OR=2.41, 95% CI=1.95-2.97), and school-aged children (Adjusted OR=1.63, 95% CI=1.26-2.12) had a significantly higher risk of adenovirus infection than newborns and young children, respectively. There was no significant difference in infection risk between males and females. The sample with the highest incidence of adenovirus infection was nasal rinse fluid (Adjusted OR=1.82, 95% CI=1.28-2.59), followed by throat swabs (Adjusted OR=1.70, 95% CI=1.25-2.32). The findings reported herein pertain to adenovirus infection in the period preceding the advent of the pandemic caused by the severe acute respiratory syndrome (SARS)-coronavirus (CoV-2). The levels were found to be significantly higher than during the post-pandemic period, with an observed increase of 1.93 times (Adjusted OR=1.93, 95% CI=1.52-2.44). These findings have the potential to inform the enhancement of medical and public health preparedness in anticipation of future adenovirus outbreaks, thereby facilitating more effective responses.

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Published

2026-09-15

How to Cite

1.
Rakmanee K, Watthanachockchai T, Boonyanuwat M, Phlykaew S, Suksudej P, Nakhonsri V, Jaihan W, Yutthanakarnwikom P, Chailurkit L-O. Retrospective Study of Adenovirus Infections at Ramathibodi Hospital (2012-2022): Investigating Risk Factors through Nucleic Acid Amplification Testing (NAAT) in Virology Laboratory Diagnostics. Dis Control J [internet]. 2026 Sep. 15 [cited 2026 Sep. 21];52(3):396-40. available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/281722

Issue

Vol. 52 No. 3 (2026): July-September

Section

Original Article

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