Chest X-ray findings in Mpox patients and the correlation between cycle threshold of Real-time PCR for Mpox relative to pneumonia and death in Bamrasnaradura Infectious Disease Institute

Authors

  • Parichut Vongthawatchai ฺBamrasnaradura Infectious Diseases Institute, Department of Disease Control
  • Panyaros Kongpanya Bamrasnaradura Infectious Disease Institute, Department of Disease Control
  • Natcha Nateniyom Bamrasnaradura Infectious Disease Institute, Department of Disease Control

DOI:

https://doi.org/10.14456/dcj.2024.33

Keywords:

Mpox, pneumonia, chest radiogragh

Abstract

Mpox is an ongoing global pandemic disease. There was the first outbreak in Thailand. The study aimed to study CXR findings of Mpox patients and describe the correlation between cycle threshold (Ct) from Real-time Polymerase Chain Reaction (Real-time PCR) for Mpox relative to pneumonia and death. This retrospective study evaluated Mpox patients treated at the Bamrasnaradura Infectious Diseases Institute during August 1, 2022 to September 30, 2023. There were 40 Mpox patients included in this study. Of these patients, 95.0% were Thai, 90.0% were male, and 55.0% were HIV positive. The average age of patients was 31.6 years. Among these patients, 15.4% were having pneumonia. The mortality rate was 5.0%. The most common CXR findings of Mpox-related pneumonia were reticular opacity (100%), bilateral lungs involvement (100%), both central and peripheral distribution (100%). Mean Ct from Real-time PCR for Mpox with pneumonia group was 19.21+1.97 and non-pneumonia group was 20.65+0.80 (p-value=0.562). Mean Ct from Real-time PCR for Mpox among fatal group was 16.32+0.18 and non-fatal group was 20.73+4.65 (p-value=0.193). Respiratory symptoms were not observed in all Mpox patients, so performing CXR was solely at the discretion of the treating physician. Lower value of Ct from Real-time PCR for Mpox that suggests higher pathogen load was not significantly correlated with pneumonia and death.

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Published

2024-09-18

How to Cite

1.
Vongthawatchai P, Kongpanya P, Nateniyom N. Chest X-ray findings in Mpox patients and the correlation between cycle threshold of Real-time PCR for Mpox relative to pneumonia and death in Bamrasnaradura Infectious Disease Institute. Dis Control J [Internet]. 2024 Sep. 18 [cited 2024 Nov. 21];50(3):409-21. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/268817

Issue

Vol. 50 No. 3 (2024): July-September

Section

Original Article

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