A 10-year retrospective study: clinical characteristics of high alert minimal inhibitory concentration in gonorrhea at Bangrak STIs Center

Authors

  • Rossaphorn Kittiyaowamarn Bangrak STIs Center, Department of Disease Control
  • Kittipoom Chinhiran Bangrak STIs Center, Department of Disease Control
  • Pongsathorn Sangprasert Bangrak STIs Center, Department of Disease Control
  • Ekkachai Daengsaard Bangrak STIs Center, Department of Disease Control
  • Natnaree Girdthep Bangrak STIs Center, Department of Disease Control
  • Chaihan Rungsirisangratana Bangrak STIs Center, Department of Disease Control

DOI:

https://doi.org/10.14456/dcj.2023.6

Keywords:

Gonorrhea, Neisseria gonorhoeae, Antimicrobial resistance N. gonorhoeae monitoring

Abstract

Gonorrhea is a sexually transmitted infection that remains a major public health concern in Thailand and globally. Thailand has been facing with the problem of antimicrobial resistance (AMR) in Neisseria gonorrhoeae. From the 10-year antibiotic susceptibility monitoring of Neisseria gonorrhoeae at Bangrak STIs Center, 8 of the 3,660 total cases were reported getting infected with the “watch list” AMR Gonorrhea. It was found that the isolates from the 6 cases had reached alert value of Azithromycin sensitivity test and revealed Azithromycin non-susceptibility. Two isolates reached the alert Cefixime minimal inhibitory concentration (MIC) but only 1 of them was not susceptible to Cefixime. However, there was no gonorrhea case report with Ceftriaxone non-susceptibility. The isolates that demonstrated Azithromycin non-susceptibility were found in genitalia, throat and anus, while 2 isolates that had Cefixime susceptibility test above MIC break point were found only in urethra. In Thailand, the first detected case of antibiotic non-susceptibility of Neisseria gonorrhoeae was reported in 2017 and the trend  has been increased. Therefore, the area coverage of AMR surveillance system in Neisseria gonorrhoeae should be expanded in Thailand. Laboratory tests should be required in gonorrhea diagnosis to guide the proper antibiotics use for reducing the problems regarding AMR in the future.

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Published

2023-03-25

How to Cite

1.
Kittiyaowamarn R, Chinhiran K, Sangprasert P, Daengsaard E, Girdthep N, Rungsirisangratana C. A 10-year retrospective study: clinical characteristics of high alert minimal inhibitory concentration in gonorrhea at Bangrak STIs Center. Dis Control J [Internet]. 2023 Mar. 25 [cited 2024 Dec. 19];49(1):62-71. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/256986

Issue

Vol. 49 No. 1 (2023): January-March

Section

Original Article

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