Guillain-Barre Syndrome (GBS) following viral vector COVID-19 vaccination (AstraZeneca) : a case report
DOI:
https://doi.org/10.14456/dcj.2023.39Keywords:
Guillain-Barre Syndrome: GBS, AstraZeneca, Adverse events following immunization: AEFI, SARS-CoV-2Abstract
Guillain-Barré Syndrome (GBS) is an immune-mediated polyneuropathy characterized by progressive symmetrical ascending paralysis of limbs and decreased or absent of deep tendon reflexes. Diagnostic workup of cerebrospinal fluids demonstrated albuminocytologic dissociation with confirmatory evidence of early demyelinating electrodiagnostic feature on nerve conduction study. The etiology of GBS is not yet clear, but it typically occurs in the post bacterial or viral infection such as Parainfluenza virus, Herpes virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Campylobacter jejuni, Mycoplasma pneumoniae, Haemophilus influenza, etc. In addition, GBS can occur after surgery, traumatic injury, and vaccination (adverse events following immunization; AEFI). We report case of a 28-year-old Thai male without comorbidity presenting with progressive numbness and weakness of both hands and feet two days after being given viral vector (AstraZeneca) COVID-19 vaccine. He received intravenous immunoglobulin (IVIg) for 5 days until fully recovery. Therefore, if there are no restrictions to access the alternative vaccine, the patient should be given a booster dose of vaccine other than viral vector platform and adequate advice about GBS from any COVID-19 vaccines under limited information.
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