Real World Effectiveness of Inactivated SARS-CoV-2 Vaccine (CoronaVac) against the COVID-19 outbreak in a hospital in northern, Thailand

Authors

  • Supalert Nedsuwan Chiangrai Prachanukroh Hospital
  • Panithee Thammawijaya Division of Epidemiology, Department of Disease Control
  • Yaowalak Jariyapongpaiboon Chiangrai Prachanukroh Hospital
  • Amornrat Wiriyaprasobchoke Chiangrai Prachanukroh Hospital
  • Chaiwetch Thanapaisal Chiangrai Prachanukroh Hospital

DOI:

https://doi.org/10.14456/dcj.2021.100

Keywords:

COVID-19, Vaccine, Effectiveness, Outbreak, Hospital

Abstract

Amidst the pandemic of Coronavirus Disease 2019 (COVID-19), vaccination is one of key measures for controlling epidemic. This study aimed to evaluate real world vaccine effectiveness (VE) of two doses of, an inactivated SARS-CoV-2 vaccine, CoronaVac, in preventing the COVID-19 infection and pneumonia during the outbreak. A retrospective cohort study was conducted. The cohort included hospital personnel working in the wards with COVID-19 cases or providing services to the COVID-19 cases during the outbreak. All participants were tested for the genetic materials (RNA) of SARS-CoV-2 in upper respiratory specimens using RT-PCR technique during June 18 – July 1, 2021 and had vaccination information from the national vaccination database of the Ministry of Public Health Immunization Center. Data analyses performed multiple logistic regression analysis for calculating aAdjusted Odds Ratios and 95% Confidence Intervals (95% CI). Vaccine effectiveness (VE) percentages were calculated, using the unvaccinated as a comparison group. The results showed that, among 431 cohort participants, 40(9.2%) were infected with COVID-19 and 336(78.0%) received the CoronaVac for at least 14 days before the outbreak started or getting infected. Effectiveness of the CoronaVac (receiving two doses for at least 14 days), adjusted for history of close contact with COVID-19 case and working in the ward with high attack rate was 89.9% (95%CI = 74.9-95.9). Unadjusted effectiveness in preventing pneumonia was 83.9% (95% CI = 16.2-96.9). The findings from this study indicated that the effectiveness of CoronaVac which was widely used in Thailand in the first half of 2021, in preventing COVID-19 infection (Alpha variant B.1.1.7) and pneumonia during that period. The vaccine seemed to play an important role in reducing morbidity and mortality among the vaccinated population

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References

Division of Communicable Disease, Department of Disease Control (TH). Guidelines for vacci¬nation against COVID-19 in Thailand’s epidemic situation in 2021. 1st ed. Nonthaburi: Division of Communicable Disease, Department of Disease Control (TH); 2021. (in Thai)

Palacios R, Batista AP, Albuquerque CSN, Patiño EG, Santos JP, Conde MTRS, et al. Efficacy and safety of a COVID-19 inactivated vaccine in healthcare professionals in Brazil: the PROFISCOV Study [Internet]. 2021 [cited 2021 Sep 26]. Available form: https://papers. ssrn.com/sol3/papers.cfm?abstract_ id=3822780.

Tanriover MD, Doğanay HL, Akova M, Güner HR, Azap A, Akhan S, et al. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a dou¬ble-blind, randomised, placebo-controlled, phase 3 trial in Turkey. Lancet. 2021;398 (10296):213-22.

Jara A, Undurraga EA, González C, Paredes F, Fontecilla T, Jara G, et al. Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile. N Engl J Med. 2021;385(10):875-84.

Vasileiou E, Simpson CR, Shi T, Kerr S, Agrawal U, Akbari A, et al. Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study. Lancet. 2021;397(10285):1646-57.

Kannangara CI, Seetulsingh P, Foley J, Bennett G, Carter T. Investigation and management of an outbreak of COVID-19 infection in an acute ad¬mission unit in a District General Hospital: les¬sons learnt. Infect Prev Pract. 2021;3(3):100156.

Wang X, Zhou Q, He Y, Liu L, Ma X, Wei X, et al. Nosocomial outbreak of COVID-19 1162

pneumonia in Wuhan, China. Eur Respir J. 2020;55(6):2000544.

Wong SCY, Kwong R-T-S, Wu TC, Chan JWM, Chu MY, Lee SY, et al. Risk of nosoco¬mial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect. 2020;105(2):119-27.

World Health Organization. Evaluation of COVID-19 vaccine effectiveness: interim guid¬ance [Internet]. Geneva: World Health Organiza¬tion; 2021 [cited 2021 Mar 17] Available from: https://apps.who.int/iris/handle/10665 /340301.

The R Foundation. The R project for statistical computing [Internet]. 2021 [cited 2021 Jul 4] Available From: https://www.R-project.org/.

Press and Public Relations Mission Unit, Infor¬mation Division. Expert from Department of Disease Control revealed the efficacy of COVID-19 vaccine used in Thailand [Internet]. Nonthaburi: Bureau of Information Office of The Permanent Secretary of MoPH; 2021 [cited 2021 Jul 22]. Available from: https://pr.moph. go.th/index.php?url=pr/detail/2/04/ 161619/. (in Thai)

Division of Epidemiology, Department of Disease Control (TH). Effectiveness of the coronavirus disease 2019 [COVID-19] vaccine in Thai health care workers, July 2021. Weekly Epidemiological Surveillance Report. 2021;52 (35):509-11. (in Thai)

Pritchard E, Matthews PC, Stoesser N, Eyre DW, Gethings O, Vihta K-D, et al. Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom. Nat Med. 2021;27:1370-8.

Widianto S, Lamb K. Hundreds of vaccinated Indonesian health workers get COVID-19, doz¬ens in hospital [Internet]. Reuters; 2021 [cited 2021 Sep 4]. Available from: https://www.re¬uters.com/world/asia-pacific/hundreds-indo-nesian-doctors-contract-covid-19-de¬spite-vaccination-dozens-2021-06-17/.

Published

2021-12-29

How to Cite

1.
Nedsuwan ศ, Thammawijaya ป, Jariyapongpaiboon เ, Wiriyaprasobchoke อ, Thanapaisal ไ. Real World Effectiveness of Inactivated SARS-CoV-2 Vaccine (CoronaVac) against the COVID-19 outbreak in a hospital in northern, Thailand. Dis Control J [Internet]. 2021 Dec. 29 [cited 2022 Jun. 25];47(Suppl 2):1151-62. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/252452

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