Hepatitis C virus: general property, drug treatment, drug resistance and mutation detection

Authors

  • Anchalee Sistayanarain Faculty of Medical Science, Naresuan University
  • Duangkamol Kunthalert Faculty of Medical Science, Naresuan University

DOI:

https://doi.org/10.14456/dcj.2022.21

Keywords:

hepatitis C virus, NS3, NS5A, NS5B, drug resistance

Abstract

Hepatitis C virus (HCV) is major course of hepatitis, cirrhosis and hepatocellular carcinoma. HCV infection occurs worldwide including Thailand. Hepatitis C virus are classified into 8 main genotypes and several subtypes. Genotypes 1-3 can be detected worldwide while genotypes 4-6 are found in some geographical areas. In Thailand, HCV genotype 3 is the most predominant (47.8%) followed by genotype 6 (34.8%) and 1 (17.4%). Treatment of HCV infection with conventional antiviral drugs encounters the limitation due to the serious side effects and drug resistance. Currently, direct-acting antivirals (DAAs) have been a promising approach for HCV therapy. DAAs are composed of NS3/4A protease inhibitors (PIs), NS5A inhibitors, NS5B nucleos(t)ide polymerase inhibitors (NIs) and NS5B non-nucleoside polymerase inhibitors (NNIs). However, drug resistance is also found to be associated with viral mutations. Detection of HCV gene mutations would be essential for the treatment. The popular method for the mutation assay is the investigating nucleotide sequence and amino acid sequence of NS3, NS5A and NS5B regions of HCV.

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Published

2022-06-29

How to Cite

1.
Sistayanarain A, Kunthalert D. Hepatitis C virus: general property, drug treatment, drug resistance and mutation detection. Dis Control J [Internet]. 2022 Jun. 29 [cited 2024 Apr. 19];48(2):239-47. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/249598

Issue

Vol. 48 No. 2 (2022): April-June

Section

Review Article

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