The development of physical sunscreen formulation containing Centella asiatica extract

Authors

  • Rachanee Watanaruangrong Raj Pracha Samasai Institute, Department of Disease Control

DOI:

https://doi.org/10.14456/dcj.2021.91

Keywords:

Physical Sunscreen, Centella Asiatica, Madecassoside

Abstract

Ultraviolet (UV) ray is a causative agent of sunburn, photoaging, and eventually skin cancer. Sunscreen was used for protection the harmful from a UV. Chemical sunscreen can stimulate an allergic reaction. Physical sunscreen was less stimulated an allergic reaction. Plant was interesting for apply to a component of physical sunscreen. Centella asiatica is a herbaceous, perennial plant in the flowering plant family Apiaceae. Madecassoside is an active ingredient form Centella asiatica extract, has an anti-redness and anti-scaling effect, reduced an effect on inflammation, and stimulated the production of collagen. The objective of this experimental research is to develop a water in oil emulsion physical sunscreen formula with 1% w/w Madecassoside. The UV protection efficiency and physical, chemical, biological stability were studied after storing in real conditions for 6 months. The study results showed three formulas with a good appearance., There were broad spectrum sunscreen protection, with critical wavelength 372.8±0.27, 375.5±0.34 and 377.5±0.46, respectively and have a good level UV-A protection with boots star rating 3 (good), UVA I / UV ratio 0.73 (high). An efficacy of UV-B protection was more than 93.3% (SPF > 15). SPF were show 16.5 ± 1.3, 23.4 ± 1.1, 42.19 ± 1.7, respectively. The first formula has a significant increased density (P <0.05)., The second formula has a significant higher pH than the limited range between 4.0-6.5. The chemical stability of Madecassoside by HPLC revealed an increased stationarity in the first formula, a decreased constancy in the second formula (p<0.5), and did not significant different stability in the third formula (p>0.5). There shown a significant biological stability with microbe tested in all three formulas. In conclusion, the third formula physical sunscreen with Centella asiatica extract, is a good effective against UV-A and UV-B rays and an unchanged physical chemical and biological stability in a real-conditions for 6 months., This formula is an appropriate for applied in a physical sunscreen in the future.

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Published

2021-12-26

How to Cite

1.
Watanaruangrong R. The development of physical sunscreen formulation containing Centella asiatica extract. Dis Control J [Internet]. 2021 Dec. 26 [cited 2024 Apr. 19];47(4):1051-62. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/247444

Issue

Vol. 47 No. 4 (2021): October-December

Section

Original Article

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Articles published in the Disease Control Journal are considered as academic work, research or analysis of the personal opinion of the authors, not the opinion of the Thailand Department of Disease Control or editorial team. The authors must be responsible for their articles.