Factors affecting adherence to treatment among newly diagnosed pulmonary tuberculosis patients registered at community hospitals in Phitsanulok province
DOI:
https://doi.org/10.14456/dcj.2021.66Keywords:
Adherence to treatment, Pulmonary tuberculosis, New cases, Community hospitalsAbstract
Tuberculosis remains a major public health problem globally, as one of the top 10 causes of death worldwide, while the global TB treatment success rate has not reached the 85% success target. Adherence matter for treatment success, especially among new case pulmonary tuberculosis patients is crucial. This research was cross-sectional survey research. The objectives are to study adherence and factors affecting adherence to treatment among newly diagnosed pulmonary tuberculosis patients registered at community hospitals in Phitsanulok province during February 2018 to January 2019. The questionnaires were mailed to study sites for data collecting. There were 394 samples in total in the study. Stepwise multiple regression was use for data analysis. The results showed that most of the samples were males, average age 52.31 years, employee (37.56%), average monthly income lower than 3,000 bath (41.62%), high level knowledge on TB (62.44%), middle level psychological stress (56.85%) was detected and most of them were high level social support (64.47%). They had high level patient’s satisfaction (74.62%), with trustful in efficacy of medication (67.26%) and high level patient’s engagement (61.42%) was also seen. Low level drug side effect (63.71) was found and high level adherence detected (74.87). The factors affecting adherence to treatment among newly diagnosed pulmonary tuberculosis patients registered at community hospitals in Phitsanulok province, were the knowledge on TB, patients’ engagement, patients’ satisfaction, psychological stress, age, trusted in efficacy of medication, gender and social support, which had a relationship with the adherence to treatment of 73.80% (adj.R2 = .738, F = 139.304, p-value <.05). In conclusion, for promotion of adherence, there should be a package of TB education and along with providing social support. More caution should be addressed on younger age, female and patients who have psychological stress, Patients’ engagement, good relationship and building trust on efficacy of medication could improve tuberculosis treatment outcome.
References
World Health Organization. THE END TB STRATEGY [Internet]. Geneva: World Health Organization; 2015 [cited 2019 Sep 3]. 26 p. Available form: https://www.who.int/tb/strategy/End_TB_Strategy.pdf
World Health Organization. GLOBAL TUBERCULOSIS REPORT 2018 [Internet]. Geneva: World Health Organization; 2018 [cited 2019 Sep 3]. 265 p. Available form: https://apps.who.int/iris/bitstream/handle/10665/274453/9789241565646-eng.pdf
Bureau of tuberculosis, Department of Disease Control. National Tuberculosis control Programme Guidelines, Thailand 2018 [Internet]. Nonthaburi: Bureau of tuberculosis; 2018 [cited 2019 Sep 3]. 190 p. Available form: https://www.tbthailand.org/download/Manual/NTP2018.pdf (in Thai)
Office of Disease Prevention and Control Region 2 Phitsanulok, Department of Disease Control. National Tuberculosis Information Program: NTIP [Internet]. Phitsanulok: Office of Disease Prevention and Control Region 2 Phitsanulok; 2019 [cited 2019 Sep 4]. Available from: https://tbcmthailand.ddc.moph.go.th (in Thai)
World Health Organization. ADHERENCE TO LONG-TERM THERAPIES: Evidence to Action [Internet]. Geneva: World Health Organization; 2003 [cited 2019 Sep 3]. 196 p. Available form: https://apps.who.int/iris/bitstream/handle/10665/42682/9241545992.pdf?sequence=1&isAllowed=y.pdf
Imperial M Z, Nahid P, Phillips P P J, Davies G R, Fielding K, Hanna D, et al. A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis. Nature Medicine [Internet]. 2018 [cited 2019 Sep 5];(24):1708–15. Available form: https://www.nature.com/articles/s41591-018-0224-2.pdf
Tang Y, Zhao M, Wang Y, Gong Y, Yin X, Zhao A, et al. Non-adherence to anti-tuberculosis treatment among internal migrants with pulmonary tuberculosis in Shenzhen, China: a cross-sectional study. BMC public health [Internet]. 2015 [cited 2019 Sep 5];(15):474 Available form: https://bmcpublichealth.biomedcentral.com/track/pdf/10.1186/s12889-015-1789-z.pdf
Comrey A L, Lee H B. A First Course in Factor Analysis. 2nd ed. Hillsdale, New Jersey: Lawrence Erlbaum Associated; 1992.
Chaimay b. Sample size determination for descriptive research in public health. Thaksin J [Internet]. 2013 [cited 2019 Sep 5];2(16):9-18. Available form: https://ph02.tci-thaijo.org/index.php/tsujournal/article/view/42935/35522.pdf (in Thai)
Bloom B S, Hastings J T, Madaus G F. Hand book on Formative and Summative Evaluation of Student Learning. New York: McGraw-Hill Book Company; 1971.
Mahadnirankul S, Poompaisanchai W, Tapanya P. The Construction of Suan Prung Stress Test for Thai Population. APPJ. 1997:13(3);1-20. (in Thai)
Best, JW. Research in Education. 10th ed. Englewood Cliffs, New Jersey: Practice; Hall; 2006
Fagundez G, Perez-Freixo H, Eyene J, Momo J C, Biyé L, Esono T, et al. Treatment Adherence of Tuberculosis Patients Attending Two Reference Units in Equatorial Guinea. PloS one [Internet]. 2016 [cited 2019 Sep 6];11(9):e0161995. Available form: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161995.pdf
Krasniqi S, Jakupi A, Daci A, Tigani B, Jupolli-Krasniqi N, Pira M, et al. Tuberculosis Treatment Adherence of Patients in Kosovo. Tuberculosis Research and Treatment. [Internet]. 2017 [cited 2019 Sep 6];(2017):1-8. Available form: https://www.researchgate.net/publication/320869423_Tuberculosis_Treatment_Adherence_of_Patients_in_Kosovo.pdf
Tesfahuneygn G, Medhin G, Legesse M. Adherence to Anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia. BMC Research Notes [Internet]. 2015 [cited 2019 Sep 7];(8):503. Available form: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1452-x#citeas.pdf
Herrero MB, Ramos S, Arrossi S. Determinants of non adherence to tuberculosis treatment in Argentina: barriers related to access to treatment. Revista Brasileira de Epidemiologia [Internet]. 2015 [cited 2019 Sep 7];18(2):287-98. Available form: https://www.scielosp.org/pdf/rbepid/2015.v18n2/287-298/en.pdf
Madeira de Oliveira S, Altmayer S, Zanon M, Alves Sidney-Filho L A, Moreira A L S, de Tarso Dalcin P, et al. Predictors of noncompliance to pulmonary tuberculosis treatment: An insight from South America. PloS one [Internet]. 2018 [cited 2019 Sep 8];13(9):e0202593. Available form: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202593.pdf
Alipanah N, Jarlsberg L, Miller C, Linh NN, Falzon D, Jaramillo E, et al. Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies. PLoS medicine [Internet]. 2018 [cited 2019 Sep 9];15(7):1-44. Available form: Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies (storage.googleapis.com).pdf
Skinner D, Claassens M. It’s complicated: why do tuberculosis patients not initiate or stay adherent to treatment? A qualitative study from South Africa. BMC infectious diseases [Internet]. 2016 [cited 2019 Sep 9];2016(16);712. Available form: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-2054-5#citeas.pdf
Gebreweld FH, Kifle MM, Gebremicheal FE, Simel LL, Gezae MM, Ghebreyesus SS, et al. Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: a qualitative study. Journal of Health, Population, and Nutrition [Internet]. 2018 [cited 2019 Sep 10];37(1):1. Available form: http://europepmc.org/article/PMC/5756387.pdf
Diefenbach-Elstob T, Plummer D, Dowi R, Wamagi S, Gula B, Siwaeya K, et al. The social determinants of tuberculosis treatment adherence in a remote region of Papua New Guinea. BMC Public Health [Internet]. 2017 [cited 2019 Sep 10];17(70):1-12. Available form: https://www.researchgate.net/publication/312308016_The_social_determinants_of_tuberculosis_treatment_adherence_in_a_remote_region_of_Papua_New_Guinea.pdf
Tola HH, Tol A, Shojaeizadeh D, Garmaroudi G. Tuberculosis Treatment Non-Adherence and Lost to Follow Up among TB Patients with or without HIV in Developing Countries: A Systematic Review. Iranian Journal of Public Health [Internet]. 2015 [cited 2019 Sep 10];44(1):1-11. Available form: https://www.researchgate.net/publication/278044617_Tuberculosis_Treatment_Non-Adherence_and_Lost_to_Follow_Up_among_TB_Patients_with_or_without_HIV_in_Developing_Countries_A_Systematic_Review.pdf
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