Ergotism risk perception among patients receiving protease inhibitors (PIs) and efavirenz (EFV) and effect of drug information consultation, Bamrasnaradura Infectious Diseases Institute, Thailand
DOI:
https://doi.org/10.14456/dcj.2019.29Keywords:
ergotism, protease inhibitors, ergotamine, efavirenz, KAPAbstract
Taking ergot derivatives, anti-migraine drugs, among HIV/AIDS patients receiving protease inhibitors (PIs) or efavirenz was known as a risk factor for ergotism. Therefore, this study aimed to investigate ergotism risk perception and effect of drug information consultation among such patients. During October and November 2018, 373 OPD patients of Bamrasnaradura Infectious Diseases Institute (BIDI) were non-randomly enrolled and face-to-face interviews were performed. It was found that 53.6% experienced headaches in their lifetime, of these 2.2% ever had ergotamine. Two cases of ergotism were diagnosed with the prevalence of 10/1,000, among those experiencing headache. 30.6% of the 373 reported having received drug information consultations with respect drug interactions between these two groups of medications. Mean scores of the Knowledge was the lowest, followed by the Practice and Attitude with 20.3%, 70.3%, and 78.8%, respectively. Comparing with the patients reporting never receiving the consultation, the multiple logistic regression analysis showed that those receiving the consultation for every visit was 76.6 (95% CI = 32.1, 182.3) and 2.2 (95% CI = 1.0, 4.7) times more likely having higher knowledge and positive behavior, respectively. Therefore, integrating and improving the existing drug consultation system could effectively decrease ergotism and any drug interaction incidence among HIV/AIDS patients.
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