Incidence and Risk Factors of Dyslipidemia in HIV-Infected Children Receiving Antiretroviral Therapy
Keywords:
Dyslipidemia, children wuth HIV infection, Protease inhibitorAbstract
This study aimed to evaluate the incidence and associated risk factors of dyslipidemia in HIV- infected children receiving protease inhibitor (PI) based regimens and the first-line regimen (2NRTIs/NNRTI). One hundred and forty HIV-infected children receiving antiretroviral therapy were enrolled and followed up for 12 months. Seventy-two children received PI based regimens in the form of boosted PI and 68 received 2NRTIs/NNRTI regimens. The mean of age onsets of current regimens in PI based group was higher than 2NRTIs/NNRTI group because all children in PI group had treatment failure from the first-line regimens. The definition for hypercholesterolemia and hypertriglyceridemia were higher than 200 mg/dl and 150mg/ dl respectively. The results showed that children on PI based regimens had risk to develop dyslipidemia nearly 9 times greater than 2NRTIs/NNRTI regimens (RR=8.88, 95%CI 4.059-19.428, P<0.01), 61.1% met criteria for hypercholesterolemia ( mean cholesterol level 220.56 ± 6.61 mg/dl) and 72.2% for hypertriglyceridemia (mean triglyceride level 255.53 ± 17.48 mg/dl ), these were significantly higher than 2NRTIs/NNRTI regimens( 25.0% for hypercholesterolemia , mean cholesterol level 184.24 ± 3.96 mg/dl and 16.2% for hypertriglyceridemia (mean triglyceride level 115.0 ± 7.67 mg/dl , P<0.01). Body mass undex (BMI) before receiving the current regimens and viral load <50 copies/ml were significantly associated with dyslipidemia. In this study, the children receiving double boosted PI regimens had no significantly higher incidence of hyperlipidemia than single boosted PI regimens. The treatment of HIV-infected children with boosted PI should be concerned for long-term complications of dyslipidemia.
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