Anti Tuberculosis Drug Resistance Surveillance Round 3 (2006-2007 ) and the Trend of Drug Resistance in Thailand
Keywords:
Anti Tuberculosis Drug Resistance in Thailand, Trend of drug resistanceAbstract
The 3rd Round of Drug Resistance Surveillance was conducted during 2006 - 2007. Seventy- six clusters in 56 provinces were recruited for the study through randomly custer sampling. 1,150 new smear positive cases and 194 cases with history of previously treated were enrolled. Multidrug resistance among new smear positive case was 1.65% and 34.54% among previously treated. Combined drug resistance to INH and RMP was 6.40%. In new smear positive cases any resistance of INH and RMP was 9.70% and 6.40% respectively while among previously treated was 44.30% and 35.10% for INH and RMP. Combined drug resistance of any H resistance and any R resistance was 14.70% and 7.30% Breaking data into regional setting, MDR in new smear positive cases was 0.78%, 1.06%, 2.93% and 3.24% in Central, Northeast, North and South respectively. But combined MDR was 9.28%, 5.95%, 4.41% and 3.17% in Central, Northeast, North and South. The findings of this round of the DRS emphasized the importance of strengthening TB control at all levels and in all stakeholders. In light of the level of resistance in the previously treated patients, the WHO CAT2 regimen for re-treatment in particular for the failure cases from CAT1 should be re-evaluated and revised if enough evidence based existed.
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