Seroprevalence of Immunity against Japanese Encepalitis in Thai population

Authors

  • พรศักดิ์ อยู่เจริญ Bureau of General Communicable Disease
  • อัจฉรียา อนุกูลพิพัฒน์ National Institute of Health, Department of Medical Sciences
  • สุรภี อนันตปรีชา National Institute of Health, Department of Medical Sciences
  • ปิยนิตย์ ธรรมาภรณ์พิลาศ Bureau of General Communicable Disease

Keywords:

Japanese Encephalitis, seroprevalence

Abstract

Serum samples collected from people living in 4 regions of Thailand in 2004 were tested for markersmof immunity against Japanese Encephalitis. The overall prevalence of protective immunity ( PRNT geometric mean titre >1:10) was 75%. The prevalence among children aged less than 2 years was 32% and in children aged 2-9 years was 69%. The prevalence decreased to 61% in children aged 10-15 years and gradually increased to 77% in age group 25-29 years. More than 90% of adult aged more than 40 years had protective immunity. Geometric mean titres by age group had increasing trend, similar to the trend of prevalence of protective immunity. Among children less than 5 years old who had received 2 and 3 doses vaccination, 65% and 84% respectively showed protective immunity. Increasing prevalence of protective immunity by age suggested endemicity of the Japanese Encephalitis infections in Thailand in the past which might have continued until recent years. Although Japanese Encephalitis vaccination has helped increase the prevalence of protective immunity in children, the proportion of immune population is still lower than the level expected. The shortfall may due to low vaccine coverage or vaccine effectiveness in the field.

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Published

2009-12-31

How to Cite

1.
อยู่เจริญ พ, อนุกูลพิพัฒน์ อ, อนันตปรีชา ส, ธรรมาภรณ์พิลาศ ป. Seroprevalence of Immunity against Japanese Encepalitis in Thai population. Dis Control J [Internet]. 2009 Dec. 31 [cited 2024 May 8];35(4):276-84. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/155955

Issue

Vol. 35 No. 4 (2009): October-December

Section

Original Article

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Articles published in the Disease Control Journal are considered as academic work, research or analysis of the personal opinion of the authors, not the opinion of the Thailand Department of Disease Control or editorial team. The authors must be responsible for their articles.