Validation of the Rapid Diagnostic Test for Dengue Fever/Dengue Hemorrhagic Fever which Detecting both Antigen and Antibody

Authors

  • วิชัย สติมัย Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health,
  • พงษ์วิทย์ บัวล้อมใบ Bureau of Vector Borne Disease, Department of Disease Control, Ministry of Public Health,
  • วิบูลย์ศักดิ์ วุฒิธนโชติ Chumpae Hospital, Kon Khan Province
  • ฑิตถากร รอดนาค Bureau of Vector Borne Disease
  • คนึงนิจ คงพ่วง Bureau of Vector Borne Disease
  • รุ่งระวี ทิพย์มนตรี Bureau of Vector Borne Disease

Keywords:

Dengue nonstructural protein 1 antigen, Rapid dengue diagnosis

Abstract

The objective of this study was to evaluate the rapid diagnostic test for Dengue and Dengue haemorrhagic fever (DF/DHF) which detecting RDT NS1 and RDT IgM/IgG (SD Bioline Dengue Duo). One hundred and seventy - three suspected DF/DHF cases from Chumpae Community Hospital, Khon Kean Province, Thailand during July - September 2009 were recruited into this study. The results showed this rapid diagnostic test detected 40 and 23 primary and secondary infective patients respectively. The sensitivity was 70.4 % and specificity was 89.9 % in acute phrase of illness while in convalescence phase, the sensitivity and specificity were 77.3 % and 86.3 % respectively. Totally, the test gave 71.4 % sensitivity and 88.9 % specificity to all patients. However, the RDT's sensitivity was deviated by the duration after onset of fever. The RDT NS1 showed the highest sensitivity in the third day ( 100 %) and the RDT IgM showed the highest sensitivity in the forth day ( 58 %). This rapid diagnostic test showed moderate sensitivity; nevertheless, it showed high specificity in both acute and convalescence phases of illness. In addition, its sensitivity showed the highest in the early phase of illness (the 3rd - 4th day after onset of illness).

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References

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Published

2011-03-31

How to Cite

1.
สติมัย ว, บัวล้อมใบ พ, วุฒิธนโชติ ว, รอดนาค ฑ, คงพ่วง ค, ทิพย์มนตรี ร. Validation of the Rapid Diagnostic Test for Dengue Fever/Dengue Hemorrhagic Fever which Detecting both Antigen and Antibody. Dis Control J [Internet]. 2011 Mar. 31 [cited 2024 Dec. 20];37(1):27-3. Available from: https://he01.tci-thaijo.org/index.php/DCJ/article/view/155604

Issue

Vol. 37 No. 1 (2011): January-March

Section

Original Article

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Articles published in the Disease Control Journal are considered as academic work, research or analysis of the personal opinion of the authors, not the opinion of the Thailand Department of Disease Control or editorial team. The authors must be responsible for their articles.