TY - JOUR AU - Channgam, Phuttipan AU - Sakcamduang, Walasinee PY - 2021/01/25 Y2 - 2024/03/29 TI - Successful management of hypoadrenocorticism in a French Bulldog by a smaller dose and lesser frequency of the desoxycorticosterone pivalate: a case report JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 51 IS - 1 SE - Clinical Reports DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/247460 SP - 197-200 AB - <p><span class="fontstyle0">A 1 year and 4 months old, intact female French Bulldog was presented because of weakness, anorexia, and<br>vomiting for 3 days. Laboratory findings included azotemia, hyponatremia, hypochloremia, sodium to potassium<br>(Na:K) ratio was 23.88, and the lower level of basal cortisol concentration than the detection limit. The small size of both<br>adrenal glands obtained from abdominal ultrasonography. Subsequently, the adrenocorticotropic hormone (ACTH)<br>stimulation test was performed, and the diagnosis of hypoadrenocorticism was confirmed. The desoxycorticosterone<br>pivalate (DOCP) with a smaller dose and lesser frequency than the recommendation of 2.2 mg/kg every 25 days. The<br>dog received DOCP subcutaneous injection at a dose of 1.5 mg/kg initially and followed by 1.37 mg/kg 55 days after<br>the first injection, 1.37 mg/kg 28 days after the second injection, and more than 84 days after a dose of 1.37 mg/kg of<br>the third injection. Glucocorticoid administrations were in recommended doses for the whole period of management.<br>Improvement of clinical manifestations and laboratory parameters of the dog was observed a week later after the DOCP<br>intervention. A smaller than recommended dose and lesser frequency of the DOCP with prednisolone seems adequate<br>for controlling clinical problems in the successful management of the hypoadrenocorticism in a French Bulldog.</span> </p> ER -