TY - JOUR AU - Villar-Perez, Víctor Manuel del AU - Barreras-Serrano, Alberto AU - Tamayo-Sosa, Alma Rossana AU - Tinoco-Gracia, Luis AU - Melgarejo, Tonatiuh PY - 2020/12/04 Y2 - 2024/03/29 TI - Evaluation of the antimicrobial activity of the K9CATH peptides of 21 and 38 amino acids against Brucella abortus and Brucella melitensis JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 50 IS - 4 SE - Short Communications DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/246371 SP - 593-597 AB - <p><span class="fontstyle0">Brucellosis is a worldwide zoonotic disease endemic in Mexico and of major economic importance to the livestock<br>industry and public health. The increase of resistance and reduced susceptibility to common anti-brucella drugs in<br>several Brucella species reported in recent studies have motivated the researchers to search for new antimicrobials<br>where the antimicrobial peptides can be an alternative. The present is a pilot study in which the in vitro antimicrobial<br>susceptibility of two bovine field strains of </span><span class="fontstyle2">B. abortus </span><span class="fontstyle0">and </span><span class="fontstyle2">B. melitensis </span><span class="fontstyle0">were evaluated against the antimicrobial peptides<br>canine cathelicidin (K9CATH) of 21 and 38 amino acids. Minimum inhibitory concentration (MIC) of 8 μg/ml for both<br>cathelicidins was obtained against </span><span class="fontstyle2">B. abortus</span><span class="fontstyle0">, while none of the cathelicidins up to 128 μg/ml inhibited </span><span class="fontstyle2">B. melitensis<br></span><span class="fontstyle0">growth. Further studies including more clinical isolates of </span><span class="fontstyle2">brucella </span><span class="fontstyle0">and the use of combinations of these peptides with<br>the conventionally prescribed anti brucellosis drugs could be useful in ascertaining whether these peptides have a<br>synergistic effect.</span> </p> ER -