TY - JOUR AU - Alfaro, Luis AU - Enciso, Alexis AU - Enciso, Javier PY - 2020/09/01 Y2 - 2024/03/28 TI - Cardiac myxoma in the pulmonary trunk of a canine: presence of mesenchymal stem-like cells JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 50 IS - 3 SE - Short Communications DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/245853 SP - 431-434 AB - <p><span class="fontstyle0">Cardiac myxoma is a rare disease in dogs. Its histogenic origin has not yet been established, but the involvement of<br>mesenchymal stem cells has been suggested in humans. Here we report an encapsulated and benign cardiac myxoma<br>located at the entrance to the pulmonary trunk of the heart of an 8-year-old male Yorkshire Terrier dog presenting<br>sudden death in the absence of clinical symptoms related to cardiac alterations. Hematoxylin/eosin staining<br>demonstrated the mixoid origin of the myxoma, showing abundant hypocellular stroma with polygonal cells, while<br>immunohistochemistry (IHC) corroborated its mesenchymal lineage with the detection of vimentin and α-SMA<br>positive cell populations. In addition, IHC showed some cell populations in the stroma to be immunoreactive to the<br>pluripotency markers Oct4 and ALDH1. In conclusion, this is the first report of the presence of mesenchymal stem-like<br>cells with an Oct4 and ALDH1-positive IHC profile in a canine cardiac myxoma.</span> </p> ER -