TY - JOUR AU - ATASEVER, Ayhan AU - SENTURK, Meryem AU - EKEBAS, Gorkem AU - YAMAN GRAM, Duygu AU - EREN, Meryem PY - 2020/09/21 Y2 - 2024/03/29 TI - The effects of pumpkin seed oil on carbon tetrachloride induced chronic hepatic damage in rats JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 50 IS - 3 SE - Original Articles DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/245843 SP - 345-351 AB - <p><span class="fontstyle0">The present study determined the possible protective effect of pumpkin seed oil (PSO) on histopathological changes<br>in liver tissue and serum alanine aminotransferase (ALT) activity, glucose, Non-Esterified Fatty Acids (NEFA) and<br>triglyceride (TG) levels on chronic liver injury induced by carbon tetrachloride (CCl</span><span class="fontstyle0">4</span><span class="fontstyle0">) in rats. A total of 80 Wistar rats<br>were divided into eight groups of ten rats each: the first group served as the control, group II was given intraperitoneal<br>0.2 mL/kg CCl</span><span class="fontstyle0">4</span><span class="fontstyle0">, twice a week for 8 weeks. Groups III-V were treated daily with PSO for 8 weeks (1, 2 and 3 mL/kg<br>respectively). Groups (VI-VIII) were administered with intraperitoneal CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">(0.2 mL/kg) twice a week and<br>simultaneously PSO for 8 weeks (1, 2 and 3 mL/kg, respectively). Groups VII and VIII showed a partial decrease of<br>steatosis in the hepatocytes while the findings in the Group VI were similar to Group II. Serum glucose, TG and NEFA<br>levels, which were increased as a result of liver toxicity, decreased significantly with the treatment of 1, 2 and 3 mL/kg<br>PSO. In addition, serum ALT activity also decreased in CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">groups given 2 and 3 mL / kg PSO.As a result, using of<br>PSO at a dose of 3 mL/kg is more effective than 1 and 2 mL/kg on the some biochemical and histopathological changes<br>in CCl</span><span class="fontstyle0">4 </span><span class="fontstyle0">induced liver damage. Further investigations on dosage and duration that produce the best result without side<br>effects, need to be performed.</span> </p> ER -