TY - JOUR AU - Chienwichai, Peerut AU - Reamtong, Onrapak PY - 2020/06/30 Y2 - 2024/03/29 TI - Application of multi-omics technologies to decipher rabies pathogenesis JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 50 IS - 2 SE - Review Article DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/243723 SP - 129-136 AB - <p><span class="fontstyle0">Rabies virus infection has affected human and animal health since ancient times and existing treatments are only<br>partially effective. A thorough understanding of rabies virus pathogenesis is required to achieve improved treatment<br>options and the eventual elimination of the disease. In recent years, multi-omics technology has emerged as a powerful<br>tool for understanding viral pathogenesis. However, multi-omics data is lacking for the rabies virus. The aim of this<br>review is to summarize our current understanding of rabies pathogenesis and its study using omics approaches. Several<br>mechanisms have been proposed to contribute to rabies pathogenesis using the results of omics studies. Using data<br>from different omics levels, we highlight the potential role of pathways involved in host immunity and cytoskeletal<br>protein expression in rabies pathogenesis. Future studies should focus on in-depth investigation of these pathways as<br>well as the discovery of potential drug targets. This review will be beneficial to scientists interested in investigating<br>viral pathogenesis with molecular tools, especially in rabies.</span> </p> ER -