TY - JOUR AU - Soonthornsit, Jeerawat AU - Anpranit, Weerachai PY - 2020/06/12 Y2 - 2024/03/29 TI - Juvenile diabetes mellitus with exocrine pancreatic insufficiency in a Thai Bangkaew dog: a case report JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 50 IS - 1 SE - Clinical Reports DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/243266 SP - 121-127 AB - <p><span class="fontstyle0">An 8-month-old intact male Thai Bangkaew bred dog presented with polyuria, polydipsia, polyphagia, exercise<br>intolerance and weight loss over 2 weeks. The serum biochemistry profiles revealed hyperglycemia, glycosuria and<br>high serum fructosamine concentrations indicating the development of diabetes mellitus. The dog had a good response<br>to a half-dose of intermediate-insulin injection twice daily monitored by the improvement of clinical signs and serum<br>fructosamine. This was supposed to be due to the partial destruction of islets of Langerhans. Two months later,<br>voluminous diarrhea with greasy stools, dry coat hair and generalized alopecia were observed. However, the clinical<br>signs of diabetes mellitus, such as polyuria and polydipsia were not noticed. The levels of canine-trypsin-like immunereactivity and cobalamin were below the normal range. This suggested exocrine pancreas loss of function. To determine<br>the etiology, serum insulin was measured revealing a very low level. On the other hand, serum canine pancreas-specific<br>lipase and C-reactive protein were in the normal range. Using ultrasonography, immune-mediated pancreatic fibrosis<br>was suspected while pancreatitis was a lesser possibility. Successful treatment was achieved with a combination of lowdose insulin, pancreatic enzymes and methylcobalamin promoting weight gain and exercise tolerance. This case was a<br>report of juvenile diabetes mellitus concurrent with exocrine pancreatic insufficiency in a Thai Bangkaew dog, which<br>had not been well recognized. Additional to the Thai Bangkaew breed, this report might be an important piece of<br>scientific knowledge that might be of potential hereditability and economic importance in the future.</span> </p> ER -