TY - JOUR AU - Klansnoh, Urapa AU - Banlunara, Wijit AU - Choisunirachon, Nan PY - 2019/03/25 Y2 - 2024/03/28 TI - Computed tomographic contrast enhancement and tumor angiogenesis in canine oral tumors JF - The Thai Journal of Veterinary Medicine JA - TJVM VL - 48 IS - 4 SE - Original Articles DO - UR - https://he01.tci-thaijo.org/index.php/tjvm/article/view/179801 SP - 573-581 AB - <p><span class="fontstyle0">The potential value of bolus tracking contrast enhanced computed tomography (CT) in the diagnosis of oral<br>tumors in dogs was investigated by examining the relationship between contrast-enhanced CT image density and<br>microvascularization. Among 20 dogs with oral tumors, aged 8 – 17 years, weight 3.6 – 40.0 kg, 13 dogs were suffering<br>with melanoma (MM), 4 with squamous cell carcinoma (SCC), and 3 with fibrosarcoma. Based on contrast-enhanced<br>CT scan, the time lag from the injection of contrast medium into the right cephalic vein until the contrast medium<br>returned to the mid-cervical external jugular vein at the level of the 4</span><span class="fontstyle0">th </span><span class="fontstyle0">cervical vertebrae significantly correlated with<br>body weight (</span><span class="fontstyle2">p </span><span class="fontstyle0">&lt; 0.01). The mean of post-contrast-enhancement increase in intra-tumor image density, measured in<br>Hounsfield Units (HU), was 127.09 ± 38.58%, with the highest values detected in SCC (166.88 ± 23.47%, </span><span class="fontstyle2">p </span><span class="fontstyle0">&lt; 0.05),<br>followed by MM (122.78 ± 37.90%) and fibrosarcoma (99.37 ± 31.58%). The mean of microvessel density (MVD, a<br>measure of vascularization determined by vWF-immunohistochemistry) of all tumors was 36.7 ± 11.7 vessels/mm</span><span class="fontstyle0">2</span><span class="fontstyle0">,<br>with the highest MVD values in SCC (47.5 ± 5.3 vessels/mm</span><span class="fontstyle0">2</span><span class="fontstyle0">, </span><span class="fontstyle2">p </span><span class="fontstyle0">&lt; 0.05), followed by MM (35.3 ± 11.6 vessels/mm</span><span class="fontstyle0">2</span><span class="fontstyle0">) and<br>fibrosarcoma (27.2 ± 6.5 vessel/mm</span><span class="fontstyle0">2</span><span class="fontstyle0">). The values for MVD and intra-tumor HU in post-contrasted-enhanced CT scans<br>significantly correlated (</span><span class="fontstyle2">p </span><span class="fontstyle0">&lt; 0.01).</span></p> ER -